发明专利
JP2009106296A New substitution mutant receptor and use thereof in nuclear receptor-based inducible gene expression system
有权
基于受体基因诱导基因表达系统的新替代突变体受体及其应用
- 专利标题： New substitution mutant receptor and use thereof in nuclear receptor-based inducible gene expression system
- 专利标题（中）： 基于受体基因诱导基因表达系统的新替代突变体受体及其应用
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申请号： JP2008304293申请日： 2008-11-28
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公开(公告)号： JP2009106296A公开(公告)日： 2009-05-21
- 发明人: PALLI SUBBA REDDY , KUMAR MOHAN BASAVARAJU , CRESS DEAN ERVIN , FUJIMOTO TED TSUTOMU
- 申请人： Intrexon Corp , イントレクソン・コーポレイションIntrexon Corporation
- 专利权人： Intrexon Corp,イントレクソン・コーポレイションIntrexon Corporation
- 当前专利权人： Intrexon Corp,イントレクソン・コーポレイションＩｎｔｒｅｘｏｎ Ｃｏｒｐｏｒａｔｉｏｎ
- 优先权： US26979901 2001-02-20; US31392501 2001-08-21
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A01K67/027 ; A61K48/00 ; A61P43/00 ; C07K14/705 ; C07K14/72 ; C12N1/00 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/10
摘要：
PROBLEM TO BE SOLVED: To provide new nuclear receptors containing substitution mutants, to provide their use in a nuclear receptor-based inducible gene expression system, and to provide a method for modulating the expression of gene in a host cell with the inducible gene expression system. SOLUTION: New substitution mutant receptors, their use in a group H nuclear receptor-based inducible gene expression system, applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms are disclosed. COPYRIGHT: (C)2009,JPO&INPIT
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