The present invention is cancer, particularly lung or esophageal cancer, or relates to the role played by TBC1D7 gene in carcinogenesis, cancer, in particular a double-stranded molecule lung cancer or esophageal cancer to one or more of TBC1D7 gene, or such two compositions comprising the chain molecules, features a method for treating and / or prevented by administering the vector or cells. The present invention also relates to using one or more overexpressed genes chosen from among TBC1D7, diagnosis of pulmonary or lung cancer, for evaluation / judgment of prognosis of patients especially with NSCLC or SCLC or esophageal cancer how also features. For that purpose, TBC1D7 is likely to serve as new biomarkers for lung cancer or esophageal cancer. Further, by using as one or more indicators and their effects on the overexpression of the TBC1D7 in lung cancer or esophageal cancer, it is also disclosed methods of identifying a compound for treating or preventing lung cancer or esophageal cancer.