发明专利
- 专利标题： Single-stranded rna molecule for gene expression control
- 专利标题（中）： 用于基因表达控制的单链RNA分子
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申请号： JP2011196742申请日： 2011-09-09
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公开(公告)号： JP2013055913A公开(公告)日： 2013-03-28
- 发明人: OKI TADAAKI , HAYASHI HIROTAKE , HAMAZAKI TOMOHIRO , SHIRAMIZU HISAO
- 申请人： Bonac Corp , 株式会社ボナック
- 专利权人： Bonac Corp,株式会社ボナック
- 当前专利权人： Bonac Corp,株式会社ボナック
- 优先权： JP2011196742 2011-09-09
- 主分类号： C12N15/113
- IPC分类号： C12N15/113
摘要：
PROBLEM TO BE SOLVED: To provide a new nucleic acid molecule suppressible of gene expression.SOLUTION: This single-stranded RNA molecule includes an expression-suppressing sequence suppressing expression of a target gene, including, from 5' side to 3' side, a 5' side region (Xc), a linker region (Lx) and a 3' side region (X) in this order; where the 5' side region (Xc) is complementary to the 3' side region (X), at least one of the 5' side region (Xc) and the 3' side region (X) contains the expression-suppressing sequence, and the molecule satisfies at least either condition of the following (1) and (2). The condition (1): a 3' terminal region of the 5' side region (Xc) and a 5' terminal region of the 3' side region (X) hybridize by a hydrogen bonding between an adenine base and a urasil base. The condition (2): at least either of the 3' terminal region of the 5' side region (Xc) and the 5' terminal region of the 3' side region (X) has a deoxyribonucleotide residue.
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