发明专利
JP2013071916A Platelet aggregation inhibitor having 3-aryloxychromone compound as active ingredient
审中-公开
具有作为活性成分的3-氰基酮化合物的平板聚集抑制剂
- 专利标题： Platelet aggregation inhibitor having 3-aryloxychromone compound as active ingredient
- 专利标题（中）： 具有作为活性成分的3-氰基酮化合物的平板聚集抑制剂
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申请号： JP2011212891申请日： 2011-09-28
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公开(公告)号： JP2013071916A公开(公告)日： 2013-04-22
- 发明人: FUJITA NAOYA , TAKAGI SATOSHI , OGO NAOHISA
- 申请人： General Incorporated Association Pharma Valley Project Supporting Organization , 一般社団法人ファルマバレープロジェクト支援機構 , Japanese Foundation For Cancer Research , 公益財団法人がん研究会
- 专利权人： General Incorporated Association Pharma Valley Project Supporting Organization,一般社団法人ファルマバレープロジェクト支援機構,Japanese Foundation For Cancer Research,公益財団法人がん研究会
- 当前专利权人： General Incorporated Association Pharma Valley Project Supporting Organization,一般社団法人ファルマバレープロジェクト支援機構,Japanese Foundation For Cancer Research,公益財団法人がん研究会
- 优先权： JP2011212891 2011-09-28
- 主分类号： C07D311/36
- IPC分类号： C07D311/36 ; A61K31/353 ; A61P7/02 ; A61P7/04 ; A61P9/00 ; A61P9/10 ; A61P35/00
摘要：
PROBLEM TO BE SOLVED: To provide a platelet aggregation inhibitor taking Aggrus as a target and having 3-phenoxychromone compound as an active ingredient, and a pharmaceutical composition containing such platelet aggregation inhibitor, used for inhibiting platelet aggregation and for the prevention and/or treatment of cancerous tumor.SOLUTION: By screening low molecular weight compounds inhibiting the Aggrus-dependent platelet aggregation and also bonding with the Aggrus and inhibiting the interaction with CLEC-2, the 3-phenoxychromone compounds, especially a 3-phenoxychromone compound having carboxyalkyleneoxy group at the 7 position is found to have an excellent behavior. Also provided are the platelet aggregation inhibitor containing the compound as the active ingredient and the pharmaceutical composition containing such platelet aggregation inhibitor, used for inhibiting the platelet aggregation and for the prevention and/or treatment of the cancerous tumor.
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