本发明能够产生异戊二烯的重组微生物，以及通过使用这样的重组微生物，涉及生产异戊二烯的高效率。 在本发明中，通过改变ISPA基因的功能活性，在遗传改造的重组细胞，以产生发酵期间异戊二烯或俯卧细胞类异戊二烯积聚会否则，生产类异戊二烯分子的 它降低。 因此，由ISPA基因的功能活性降低，它能够提高在宿主微生物中的异戊二烯的合成。

The present invention provides a recombinant microorganism capable of producing isoprene, as well as using such a recombinant microorganism, relates to the production of isoprene with high efficiency. In the present invention, by changing the functional activity of the ispA gene, in genetically engineered recombinant cell to produce isoprene or in susceptible cells isoprenoids accumulates during fermentation would otherwise, the production of isoprenoid molecules It is reduced. Thus by functional activity of the ispA gene is reduced, thereby enhancing the isoprene synthesis in a host microorganism.