This application, anti-P- cadherin antibody, discloses antibody drug conjugate of the antigen-binding fragment, and said antibody or antigen-binding fragment. The present invention also provides antibodies, antigen-binding fragments, and antibody drug using conjugated to a method of treating cancer. Further, the antibody, antigen-binding fragments, and methods of making antibody drug conjugates, and methods of using the antibodies and antigen-binding fragments as diagnostic agents, are disclosed herein.