To provide a building structure suppressed in occurrence of irregularities in an interior panel, while suppressing lowering of heat insulating property of the building structure.SOLUTION: A building structure 1 has: a skeleton 50 having multiple columns 51 and reinforcements provided to bridge between adjacent columns for reinforcing the columns; a frame body provided inside the columns and having outer frames 11a and an opening 11b surrounded by the outer frames; a first heat insulation part 12 filled in the opening of the frame body; a second heat insulation part 13 having higher flexibility than the first heat insulation part and provided around the reinforcements between the adjacent columns; and a third heat insulation part 14 harder than the second heat insulation part, extended outward from the first heat insulation part and connected to the second heat insulation part at a position outside the frame body.SELECTED DRAWING: Figure 1