Based on capsaicin receptor VR1 activation inhibitory action, nociceptive pain, neuropathic pain, cancer pain, headache, etc. bladder dysfunction, to provide a new and excellent therapeutic or prophylactic agent.
Has a benzene ring monocyclic on the nitrogen atom of the amide group are condensed, benzamide derivative characterized by having an amino group substituted with an adjacent position to the lower alkylamino or cyclic group of the amide group, strong VR1 activation inhibitory action, and confirmed to have an excellent pharmacological action based thereon, nociceptive pain, neuropathic pain, cancer pain, headache, bladder function disorder and the like, a good diseases involving VR1 the present invention has been completed by finding that can be a therapeutic or prophylactic agent.