The present invention, nucleotide sequence shown in SEQ ID NO: 1, or a DNA consisting of the partial nucleotide sequence the same or substantially the same base sequence comprising at least one HRE consensus sequence, transiently under hypoxia to, and DNA having a vascular endothelial cell-specific transcription promoting activity, also relates to such a vector comprising a promoter comprising the DNA. By then connecting the prevention and / or therapeutic genes or reporter gene downstream of the vector is administered to a mammal, the prevention of acute ischemic disease and / or treatment, and diagnosis can be performed.
The present invention can provide a means for detecting at an early stage of onset of acute ischemic diseases such as myocardial infarction. Also it is possible to provide a novel and effective prophylactic and / or therapeutic means of drug delivery systems, as well as acute ischemic diseases capable of delivering efficiently the drug to the lesion site of the disease.