本发明证实了对人类肝细胞提取物或红参提取物的单一处理或其对人肝细胞的混合物的处理抑制了胆固醇合成细胞，并证实了提取物和提取物的浓度，其是抑制胆固醇合成最有效的。 本发明通过测定西红柿和红参提取物的混合物中的细胞内胆固醇代谢相关酶的活性来确认提取物混合物对酶的活性的作用，多酚是作为单一的Rubus occidentalis和人参皂苷的单一物质的多酚 红参的物质; 并了解提取物对细胞内HDL / LDL相关基因表达的影响。 根据Rubus occidentalis和红参提取物的筛选结果，未成熟果实中单一物质的咖啡酸，枸橼酸，阿魏酸和没食子酸对西红柿和人参皂甙Rd，人参皂甙具有胆固醇抑制作用 -Rf和人参皂苷-Rg2都是红参中胆固醇的抑制作用。

The invention then processes the liver bokbunja extract and ginseng extract alone treatment or as a mixture to a person checking the cholesterol synthesis inhibitory effect of the cells was confirmed that the extraction solvent and extract concentration of the most effective extract of inhibiting the cholesterol synthesis. Bokbunja and red ginseng extract the mixture, and the measured single substance of polyphenols with a single material of intracellular cholesterol, the activity of metabolic enzymes of Ginseniside flow of red ginseng the bokbunja determine the effect of the extract liquid mixture on the activity of the enzyme, and these extracts It was to determine the effect on expression of the HDL / LDL-associated genes in the cell.
According to the result of screening of an extract of Rubus coreanus and red ginseng, bokbunja a single substance of caffeic acid (caffeic acid), Eli alginic acid (elligic acid), Peru acid (ferulic acid) and ground acid (gallic acid) of the immature Among these extracts and Red ginseng has been found of a single material of ginsenoside -Rd, ginsenoside ?? Rf, ginsenoside -Rg2 material having a cholesterol-suppressing effect of the extract.