发明授权
- 专利标题： Precise delivery of therapeutic agents to cell mitochondria for anti-cancer therapy
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申请号： US14902514申请日： 2014-07-01
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公开(公告)号： US10004809B2公开(公告)日： 2018-06-26
- 发明人: Shanta Dhar , Rakesh Pathak
- 申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
- 申请人地址： US GA Athens
- 专利权人： University of Georgia Research Foundation Inc.
- 当前专利权人： University of Georgia Research Foundation Inc.
- 当前专利权人地址： US GA Athens
- 代理机构： Meunier Carlin & Curfman LLC
- 国际申请： PCT/US2014/045131 WO 20140701
- 国际公布： WO2015/002996 WO 20150108
- 主分类号： C07F9/54
- IPC分类号： C07F9/54 ; A61K47/48 ; A61K47/59 ; A61K47/54 ; A61K45/06 ; A61K31/663 ; A61K31/675 ; C07F9/6518 ; A61K9/51
摘要：
Described is a targeted molecular scaffold for construction of a metabolic inhibitor loaded with cancer-cell specific activity and anti-tumor immunity. Incorporation of a mitochondria targeting moiety such as triphenylphosphonium cation through a biodegradable linker in allowed for mitochondria targeting of certain metabolic inhibitors like dichloroacetic acid (DCA).
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