Invention Grant
- Patent Title: Recombinant polypeptide production
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Application No.: US14775233Application Date: 2014-03-12
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Publication No.: US10006026B2Publication Date: 2018-06-26
- Inventor: Katie Streicher , Jonathan Jacobs , Robert W. Georgantas, III , Lydia Greenlees , Koustubh Ranade , Michael Bowen
- Applicant: MedImmune, LLC
- Applicant Address: US MD Gaithersburg
- Assignee: MedImmune, LLC
- Current Assignee: MedImmune, LLC
- Current Assignee Address: US MD Gaithersburg
- International Application: PCT/US2014/024512 WO 20140312
- International Announcement: WO2014/159633 WO 20141002
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C12P21/02 ; C07K14/705 ; C07K16/00 ; C07K16/42 ; C12N9/00
Abstract:
Disclosed herein is a method for producing a recombinant polypeptide in a mammalian cell culture in which the mammalian cells have a modified microRNA activity level. In one embodiment, a microRNA activity level is increased. In another embodiment, a microRNA activity level is decreased. In a more particular embodiment, the mammalian cells have a reduced miRNA-let-7a activity level.
Public/Granted literature
- US20160024502A1 RECOMBINANT POLYPEPTIDE PRODUCTION Public/Granted day:2016-01-28
Information query
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