A roll-diaphragm compressor and a roll-diaphragm compressors system, including methods for manufacturing and using same. The roll-diaphragm compressor includes a compressor body having a concave portion that defines a rounded interface wall and an apex portion adjacent to the concave portion that comprises an inlet and outlet port. The roll-diaphragm compressor also includes a flexible roll-diaphragm coupled to the compressor body about a compressor body edge and a compression chamber defined by the concave portion, apex portion and roll-diaphragm. The roll-diaphragm compressor further includes a piston head rigidly coupled to a central portion of the roll-diaphragm and configured to drive the roll-diaphragm to a first configuration where the roll-diaphragm engages the interface wall as part of a compression cycle.