Techniques for supporting communication in an asynchronous TDD wireless network are described. In an aspect, downlink transmissions and uplink transmissions may be sent on different carriers in an asynchronous TDD wireless network to mitigate interference. In one design, a station (e.g., a base station or a UE) may send a first transmission on a first carrier in a first time period and may receive a second transmission on a second carrier in a second time period. The station may only transmit, or only receive, or neither in each time period. In one design, allocation of carriers for the downlink and uplink may be performed when strong interference is detected, e.g., by a base station or a UE. When strong interference is not detected, the first and second carriers may each be used for both the downlink and uplink.