Invention Grant
- Patent Title: Pyrazolopyridines and pyrazolopyrimidines
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Application No.: US15342601Application Date: 2016-11-03
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Publication No.: US10022376B2Publication Date: 2018-07-17
- Inventor: Jotham Wadsworth Coe , Christoph Martin Dehnhardt , Peter Jones , Yogesh Anil Sabnis , Joseph Walter Strohbach , Florian Michel Wakenhut , Gavin Alistair Whitlock
- Applicant: Pfizer Inc.
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- Agent A. David Joran
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D487/04 ; A61K31/519 ; A61K31/437 ; A61K31/4725

Abstract:
A compound having the structure: or a pharmaceutically acceptable salt or solvate thereof, wherein A and A′ are C or N, where C may be substituted by halo or C1-C6 alkyl; R and R0 are selected from the group consisting of H, C1-C6 alkyl, —(CH2)n—W, etc., where W is 5- or 6-membered heteroaryl or heterocyclic containing N, S and/or O atoms, —NR″SO2—R′, etc., where R′ and R″ are C1-C6 alkyl, etc.; wherein each alkyl, etc., may be substituted; or, R and Ro and the N atom to which they are bonded together to form a monocyclic or bicyclic heterocyclic ring, etc.; R1 is H, halo or cyano; R2 and R2′ are H, C1-C6 alkyl, etc.; X is a bond, etc.; R3 is H, C1-C4 alkyl, etc.; Y is a bond, —(CH2)m—, etc. The invention also relates to compositions and uses in the treatment of various diseases.
Public/Granted literature
- US20170071946A1 PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES Public/Granted day:2017-03-16
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