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公开(公告)号:US5268453A
公开(公告)日:1993-12-07
申请号:US918953
申请日:1992-07-30
申请人: Robin J. Andy , Eric R. Larson
发明人: Robin J. Andy , Eric R. Larson
CPC分类号: C07K14/62 , A61K38/00 , Y10S514/866
摘要: Human insulin analogs are disclosed. These analogs are tissue-selective. Accordingly, pharmaceutical formulations containing the analogs of the invention provide superior clinical benefits as compared to human insulin when used in the treatment of patients suffering from diabetes. The analogs are modified at amino residue A12, A15 or A19, are different from the naturally occurring residue at said position, and are hepatoselective. Also disclosed are human insulin analogs modified at amino acid residues A12 or A14 or amino acid residues A10 and A13 different from naturally occurring residues or residues at said position or positions and are peripheral selective. DNA sequences and microorganisms comprising sequences coding for human insulin analogs are also provided. Processes for preparing the human insulin analogs are described.
摘要翻译: 人胰岛素类似物被公开。 这些类似物是组织选择性的。 因此,当用于治疗患有糖尿病的患者时,与人胰岛素相比,含有本发明类似物的药物制剂提供了优异的临床益处。 类似物在氨基残基A12,A15或A19处被修饰,与所述位置处的天然存在的残基不同,并且是肝选择性的。 还公开了在氨基酸残基A12或A14处修饰的人胰岛素类似物或在所述位置或位置处与天然存在的残基或残基不同的氨基酸残基A10和A13,并且是周边选择性的。 还提供了包含编码人胰岛素类似物的序列的DNA序列和微生物。 描述了制备人胰岛素类似物的方法。
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公开(公告)号:US20230120188A1
公开(公告)日:2023-04-20
申请号:US18060864
申请日:2022-12-01
申请人: Pfizer Inc.
发明人: Shelley ALLEN , Patrick Michael DOERNER BARBOUR , James Francis BLAKE , Sydney Taylor BLANCHE , Mark Laurence BOYS , Wesley Dewitt CLARK , Connor James COWDREY , Joshua Ryan DAHLKE , Alex Andrew KELLUM , Ellen Margaret KNAPP , David Austin MORENO , Jacob Matthew O'LEARY , Li REN , Faith Elizabeth WITKOS
IPC分类号: C07D471/04 , A61P35/00 , A61K31/4375 , A61K45/06
摘要: The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.
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公开(公告)号:US11603384B2
公开(公告)日:2023-03-14
申请号:US17400938
申请日:2021-08-12
申请人: Pfizer Inc.
IPC分类号: C07K1/107 , A61K39/095 , C07K14/34 , C07K14/22 , C07K14/315 , A61K39/09 , A61K47/64 , C07H3/06 , A61K39/00
摘要: The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.
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公开(公告)号:US20230061858A1
公开(公告)日:2023-03-02
申请号:US17786722
申请日:2020-12-17
申请人: Pfizer Inc.
发明人: Abraham Leung , Matthew Sung
摘要: The present disclosure provides for dosing regimens for the treatment of patients with cancer, particularly a HER2-expressing cancer, with an anti-HER2 antibody-drug conjugate (ADC). The present disclosure further provides for methods for the treatment of patients with cancer in which an anti-HER2 ADC is administered. In one embodiment, the anti-HER2 ADC is T(kK183C+K290C)-vc0101 (PF-06804103), in which the antibody T(kK183C+K290C) is linked to the auristatin drug 2-methylalanyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2 -phenyl-1-(1,3-thiazol-2-yl) ethyl]amino}propyl]pyrrolidin-1-yl}-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide (also known as “0101”) via the cleavable linker maleimidocaproyl-valine-citmlline-p-aminobenzyloxycarbonyl (also known as “vc”).
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公开(公告)号:US20230053328A9
公开(公告)日:2023-02-16
申请号:US17613304
申请日:2020-05-21
申请人: Pfizer Inc.
IPC分类号: C07K16/28 , C07K14/705 , A61K45/06 , A61P35/00
摘要: This invention relates to a method for treating cancer by administering a CDK4/6 inhibitor or CDK2/4/6 inhibitor in combination with a 4-1BB agonist and/or an OX40 agonist to a subject in need thereof.
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公开(公告)号:US20230045252A1
公开(公告)日:2023-02-09
申请号:US17939375
申请日:2022-09-07
申请人: PFIZER INC.
发明人: Matthew Frank BROWN , Alpay DERMENCI , Andrew FENSOME , Brian Stephen GERSTENBERGER , Matthew Merrill HAYWARD , Dafydd Rhys OWEN , Stephen Wayne WRIGHT , Li Huang XING , Xiaojing YANG
IPC分类号: C07D487/04 , A61K31/4985
摘要: A compound compound having the structure: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein A, A′ and A″ are independently O, C═O, C—R′ or N—R″, where R′ and R″ may independently be H, amino, —NR7COR6, COR6, —CONR7R8, C1-C6 alkyl, or hydroxy(C1-C6 alkyl), and R″ may be present or absent, and is present where the rules of valency permit, and where not more than one of A, A′ and A″ is O or C═O; R0 and R are independently H, Br, Cl, F, or C1-C6 alkyl; R1 is H, C1-C6 alkyl, or hydroxy(C1-C6 alkyl); R2 is selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, hydroxy(C1-C6 alkyl), phenyl(C1-C6 alkyl), formyl, heteroaryl, heterocyclic, —COR6, —OCOR6, —COOR6, —NR7COR6, —CONR7R8, and —(CH2)n—W, where W is cyano, hydroxy, C3-C8 cycloalkyl, —SO2NR7R8, and —SO2—R9, where R9 is C1-C6 alkyl, C3-C8 cycloalkyl, heteroaryl, or heterocyclic; wherein each of said alkyl, cycloalkyl, heterocyclic, or heteroaryl may be unsubstituted or substituted by halo, cyano, hydroxy, or C1-C6 alkyl; X is C—R3 or N, where R3 may be H or C1-C6 alkyl; R4 and R5 are independently H, amino, C1-C6 alkyl, or hydroxy(C1-C6 alkyl); R6, R7 and R8 are each independently H, C1-C6 alkyl, C1-C4 alkoxy(C1-C6 alkyl), or C3-C8 cycloalkyl, said C1-C6 alkyl is optionally substituted by halo, CN or hydroxy; or, R7 and R8 together with the atom bonded thereto form a 5- or 6-membered ring, said ring being optionally substituted by halo, hydroxy, CN, or C1-C6 alkyl; and, n is 0, 1, 2 or 3. Also provided are methods of treatment as Janus Kinase inhibitors and pharmaceutical compositions containing the compounds of the invention and combinations thereof with other therapeutic agents.
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公开(公告)号:US20220378897A1
公开(公告)日:2022-12-01
申请号:US17814281
申请日:2022-07-22
申请人: Pfizer Inc.
IPC分类号: A61K39/09 , A61K39/385 , A61K39/39
摘要: The invention relates to activated Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides and processes for their preparation. The invention also relates to immunogenic conjugates comprising Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides covalently linked to a carrier protein, processes for their preparation and immunogenic compositions and vaccines comprising them.
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公开(公告)号:US11512070B2
公开(公告)日:2022-11-29
申请号:US17085534
申请日:2020-10-30
申请人: Pfizer Inc.
发明人: Gary Erik Aspnes , Scott W. Bagley , John M. Curto , Matthew S. Dowling , David Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Gajendra Ingle , Wenhua Jiao , Chris Limberakis , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC分类号: C07D401/14 , A61K31/496 , A61K31/4545 , C07D487/04 , A61P3/00 , A61P15/10 , A61P17/06 , A61P9/10 , A61P19/06 , A61P25/28 , A61P25/30 , A61P43/00 , A61P1/16 , A61P25/02 , A61P3/04 , A61P19/02 , A61P3/10 , A61P13/12 , A61P25/18 , A61P1/00 , A61P15/00 , A61P25/16 , C07D405/14 , C07D413/14 , C07D471/04
摘要: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
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9.
公开(公告)号:US20220363673A1
公开(公告)日:2022-11-17
申请号:US17619912
申请日:2020-06-24
申请人: Pfizer Inc.
发明人: Samit Kumar Bhattacharya , Christopher Ryan Butler , Kevin James Filipski , Bethany Lyn Kormos , Luis Angel Martinez-Alsina , Russell Alan Miller , Kiyoyuki Omoto , Brian Raymer , Matthew Richard Reese , Rachel Jane Roth Flach , Yuan Zhang
IPC分类号: C07D409/04 , A61K45/06 , A61K31/41 , A61P3/10 , A61P9/04
摘要: Described herein are compounds of Formula I, wherein R1, R2, and R3 are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetes, NASH and heart failure.
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公开(公告)号:US11492346B2
公开(公告)日:2022-11-08
申请号:US16902515
申请日:2020-06-16
申请人: Pfizer Inc. , CTXT PTY LTD
发明人: Ylva Elisabet Bergman Bozikis , Michelle Ang Camerino , Pei-Pei Kung , Paul Anthony Stupple , Scott Channing Sutton
IPC分类号: C07D413/06 , A61P35/04 , A61K45/06
摘要: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Ring A, R1-R8, and n are defined herein. The novel benzisoxazole sulfonamide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in patients. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in patients.
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