- 专利标题： Oligomer-conjugate complexes and their use
-
申请号： US14342196申请日： 2012-08-29
-
公开(公告)号： US10023861B2公开(公告)日： 2018-07-17
- 发明人: Thazha P. Prakash , Eric E. Swayze , Walter F. Lima , Garth A. Kinberger
- 申请人： Thazha P. Prakash , Eric E. Swayze , Walter F. Lima , Garth A. Kinberger
- 申请人地址： US CA Carlsbad
- 专利权人： Ionis Pharmaceuticals, Inc.
- 当前专利权人： Ionis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 代理机构： McNeill Baur PLLC
- 国际申请： PCT/US2012/052884 WO 20120829
- 国际公布： WO2013/033230 WO 20130307
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C12N15/113 ; C12N15/11 ; C07H21/00
摘要：
Oligonucleotides, chemically-modified oligonucleotides, and oligonucleotide-conjugate complexes for use in research, diagnostics, and/or therapeutics are described herein. In some embodiments, oligonucleotides comprising a stabilized phosphate moiety covalently attached to the 5′-terminal nucleoside are provided.
公开/授权文献
- US20150018540A1 OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE 公开/授权日：2015-01-15