- Patent Title: Coumarin based Hsp90 inhibitors with urea and ether substituents
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Application No.: US15035610Application Date: 2014-11-11
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Publication No.: US10030006B2Publication Date: 2018-07-24
- Inventor: Brian S. J. Blagg , Huiping Zhao
- Applicant: University of Kansas
- Applicant Address: US KS Lawrence
- Assignee: UNIVERSITY OF KANSAS
- Current Assignee: UNIVERSITY OF KANSAS
- Current Assignee Address: US KS Lawrence
- Agency: Parker Highlander PLLC
- International Application: PCT/US2014/065059 WO 20141111
- International Announcement: WO2015/070238 WO 20150514
- Main IPC: C07D405/12
- IPC: C07D405/12 ; C07D405/14 ; C07D413/12 ; A61K31/352 ; A61K31/4025 ; A61K31/453 ; A61K31/496 ; A61K31/5377 ; A61K45/06 ; C07D311/16 ; G16H50/50
Abstract:
Compounds of the formulas: wherein: R1-R4, X1, Y1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.
Public/Granted literature
- US20160289217A1 COUMARIN BASED HSP90 INHIBITORS WITH UREA AND ETHER SUBSTITUENTS Public/Granted day:2016-10-06
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