公开(公告)号：US09994556B2

公开(公告)日：2018-06-12

申请号：US15318351

申请日：2015-06-12

Applicant: THE UNIVERSITY OF KANSAS

Inventor： Jinbo Zhao ,  Huiping Zhao ,  Brian S. J. Blagg

IPC: C07D405/14 ,  C07D401/12

CPC classification number: C07D405/14 ,  C07D401/12

Abstract: Provided herein are compounds of the formulas: which are 90-kDa heat shock protein inhibitors. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including cancer, e.g., cancers of the breast, the prostate, and the head & neck.

公开(公告)号：US10745386B2

公开(公告)日：2020-08-18

申请号：US16018439

申请日：2018-06-26

Applicant: University of Kansas

Inventor： Brian S. J. Blagg ,  Huiping Zhao

IPC: C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  G16H50/50 ,  A61K31/352 ,  A61K31/4025 ,  A61K31/453 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07D311/16 ,  G06F19/00

Abstract: Compounds of the formulas: wherein: R1-R4, X1, Y1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.

公开(公告)号：US10689344B2

公开(公告)日：2020-06-23

申请号：US15034957

申请日：2014-11-07

Applicant: University of Kansas

Inventor： Brian S. J. Blagg ,  Huiping Zhao

IPC: C07D211/46 ,  C07D401/12 ,  C07C235/56 ,  C07D207/08 ,  C07D211/22 ,  C07D487/08 ,  C07D451/06 ,  A61K31/167 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4458 ,  A61K31/4465 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/46 ,  A61K45/06 ,  C07D409/12

Abstract: Compounds of the formulas are provided: wherein variables Y1-Y5, X1-X5, A1-A4, X, y, n1, n2, and R1-R15 are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are useful for the treatment of a disease or disorder, including, for example, a proliferative disease, such as cancer.

公开(公告)号：US10030006B2

公开(公告)日：2018-07-24

申请号：US15035610

申请日：2014-11-11

Applicant: University of Kansas

Inventor： Brian S. J. Blagg ,  Huiping Zhao

IPC: C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  A61K31/352 ,  A61K31/4025 ,  A61K31/453 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07D311/16 ,  G16H50/50

Abstract: Compounds of the formulas: wherein: R1-R4, X1, Y1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.