- 专利标题: Cardiac tissue constructs and methods of fabrication thereof
-
申请号: US14650227申请日: 2013-12-06
-
公开(公告)号: US10034738B2公开(公告)日: 2018-07-31
- 发明人: Nimalan Thavandiran , Milica Radisic , Peter Zandstra
- 申请人: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
- 申请人地址: CA Toronto, ON
- 专利权人: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
- 当前专利权人: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
- 当前专利权人地址: CA Toronto, ON
- 代理机构: Hill & Schumacher
- 代理商 Lynn C. Schumacher
- 国际申请: PCT/CA2013/050940 WO 20131206
- 国际公布: WO2014/085933 WO 20140612
- 主分类号: A61F2/02
- IPC分类号: A61F2/02 ; A61L27/24 ; A61L27/38 ; C12N5/071 ; C12N5/077 ; C12M3/00 ; C12M1/42 ; C12M1/12
摘要:
Methods and devices are provided for the formation of cardiac tissue constructs. In some embodiments, methods are provided for forming cardiac tissue constructs that including cardiomyocytes, non-myocytes, and extracellular matrix, and which exhibit properties associated with healthy cardiac tissue. In some embodiments, microfabrication platforms are provided to support the transmission of dynamic electromechanical forces, such that the cardiac microtissue constructs may be formed mimicking the basic microenvironment found in the heart. The microfabrication platform may include retaining features for stabilizing the position of the microtissue construct during its formation, and the microfabrication platform may include a ramped support configured to produce tissue constructs having a ring geometry. In some embodiments, the microfabrication platform may be configured to for the application of point electrical stimulation, and/or to amplify the transduction of force into a visible displacement.
公开/授权文献
信息查询
IPC分类: