- 专利标题: Method of manufacturing stereoisomers of buprenorphine and analogues thereof
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申请号: US15557311申请日: 2016-03-11
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公开(公告)号: US10035807B2公开(公告)日: 2018-07-31
- 发明人: Stefan Sahli , Beat Theodor Weber
- 申请人: SIEGFRIED AG
- 申请人地址: CH Zofingen
- 专利权人: SIEGFRIED AG
- 当前专利权人: SIEGFRIED AG
- 当前专利权人地址: CH Zofingen
- 代理机构: Millen White Zelano and Branigan, PC
- 优先权: EP15158586 20150311
- 国际申请: PCT/EP2016/055249 WO 20160311
- 国际公布: WO2016/142506 WO 20160915
- 主分类号: C07D489/12
- IPC分类号: C07D489/12
摘要:
The present invention relates to a method of preparing a compound of Formula II-a′ or Formula II-b′, wherein RI represents hydrogen or a linear, branched and/or cyclic alkyl or alkenyl group having 1 to 10 carbon atoms;RII represents a linear, branched and/or cyclic alkyl or alkenyl group having 1 to 10 carbon atoms; RIII represents hydrogen or a linear, branched and/or cyclic alkyl or alkenyl group having 1 to 10 carbon atoms or a linear, branched and/or cyclic alkoxy group having 1 to 10 carbon atoms; RIV represents hydrogen or a linear, branched and/or cyclic alkyl group having 1 to 10 carbon atoms or an optionally substituted aryl or alkylaryl group having 6 to 40 carbon atom or acetyl or silyl or a protective group; and RV represents hydrogen or a methyl group; wherein RI and RII are different from each other.
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