Invention Grant
- Patent Title: Process for the preparation of 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethanone and derivatives thereof
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Application No.: US15515271Application Date: 2015-10-07
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Publication No.: US10040745B2Publication Date: 2018-08-07
- Inventor: Denis Gribkov
- Applicant: SYNGENTA PARTICIPATIONS AG
- Applicant Address: CH Basel
- Assignee: SYNGENTA PARTICIPATIONS AG
- Current Assignee: SYNGENTA PARTICIPATIONS AG
- Current Assignee Address: CH Basel
- Priority: EP14188744 20141014
- International Application: PCT/EP2015/073118 WO 20151007
- International Announcement: WO2016/058881 WO 20160421
- Main IPC: C07C45/46
- IPC: C07C45/46 ; C07C45/63 ; C07C201/00 ; C07C205/00 ; C07C201/08 ; C07C201/12 ; C07C205/45

Abstract:
A process for the preparation of a compound of formula (I) wherein R1 is hydrogen, fluoro or chloro; which process comprises: a) reacting a compound of formula (II) wherein R1 is hydrogen, fluoro or chloro; with a nitration agent to the compound of formula (III) wherein R1 is hydrogen, fluoro or chloro; b) reacting the compound of formula (III) with trichloroisocyanuric acid in the presence of sulfuric acid or fuming sulfuric acid to the compound of formula (IV) wherein R1 is hydrogen, fluoro or chloro; and c) reacting the compound of formula (III) with chlorine gas at a temperature from 180° C. to 250° C. to the compound of formula (I).
Public/Granted literature
- US20170217865A1 PROCESS FOR THE PREPARATION OF 1-(3,5-DICHLOROPHENYL)-2,2,2-TRIFLUOROETHANONE AND DERIVATIVES THEREOF Public/Granted day:2017-08-03
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