公开(公告)号：US20220233445A1

公开(公告)日：2022-07-28

申请号：US17658078

申请日：2022-04-05

申请人： Nitto Denko Corporation

发明人： Kwok Yin Tsang ,  Bharat Majeti ,  John Gaudette ,  Roger Adami ,  Hao Bai ,  Wenbin Ying

IPC分类号： A61K9/127 ,  A61K47/10 ,  A61K47/69 ,  A61K31/7105 ,  A61K47/14 ,  C07C201/00

摘要： Fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, compounds, compositions and methods are to provide nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.

公开(公告)号：US20190218169A1

公开(公告)日：2019-07-18

申请号：US16243232

申请日：2019-01-09

申请人： Eastman Chemical Company

发明人： Stephanie Kay Clendennen ,  Vasudev R. Bhonde ,  Damon Ray Billodeaux ,  Matthew Allen Boone ,  Kim Dumoleijn ,  Stijn Simonne Paul Van de Vyver ,  Kristof Moonen ,  Neil Warren Boaz

IPC分类号： C07C207/02 ,  C07C201/00 ,  C11D1/75 ,  C11D1/83 ,  C11D1/835 ,  C11D1/94 ,  C11D3/395 ,  C11D3/39 ,  C11D11/00 ,  C11D3/43 ,  C09D7/63 ,  C09K8/584 ,  C10L1/18

CPC分类号： C07C211/04 ,  A61K8/416 ,  A61K8/44 ,  A61K8/466 ,  A61Q5/02 ,  A61Q19/10 ,  C07C201/00 ,  C07C207/02 ,  C07C229/12 ,  C07C309/14 ,  C07H5/06 ,  C09D7/63 ,  C09K8/584 ,  C10L1/18 ,  C11D1/75 ,  C11D1/83 ,  C11D1/835 ,  C11D1/90 ,  C11D1/94 ,  C11D3/3942 ,  C11D3/395 ,  C11D3/43 ,  C11D11/0017 ,  C11D11/0023

摘要： The invention provides branched trialkylamine oxides with improved properties. The trialkylamine oxides of the invention produced from branched trialkylamines, in one embodiment, can be made using certain branched C10-12 enals and aldehydes. The invention also provides an trialkylamine oxide having the formula: wherein R5, R6 and R7 are independently at least one of C3H7, C2H5, CH3, or H, or mixtures thereof; and wherein R5 and R6 are not H at the same time. In one embodiment, the trialkylamine oxides of the invention can be useful in making various products, for example, as surfactants.

公开(公告)号：US5313009A

公开(公告)日：1994-05-17

申请号：US135569

申请日：1993-10-14

申请人： Alfred A. Guenkel ,  John M. Rae ,  Edward G. Hauptmann

发明人： Alfred A. Guenkel ,  John M. Rae ,  Edward G. Hauptmann

IPC分类号： B01J19/24 ,  B01J19/26 ,  C07C201/08 ,  C07C205/06 ,  C07C205/12 ,  C07C201/00 ,  B01D3/00

CPC分类号： B01J19/2415 ,  B01J19/26 ,  C07C201/08 ,  B01J2219/00081 ,  B01J2219/00159 ,  B01J2219/00166 ,  B01J2219/00186

摘要： A continuous process to nitrate a nitratable aromatic compound in a nitronium ion solution in a nitrator. The process comprises feeding into the nitrator nitronium ion solution of a composition within an area defined by connecting three points in a ternary phase diagram of nitric acid, sulfuric acid and water. The three points correspond to first about 82% of sulfuric acid and 18% nitric acid, secondly about 55% sulfuric acid and about 45% water and, thirdly, 100% sulfuric acid, with the nitric acid preferably being below about 3%. The nitratable aromatic compound is introduced in a manner such that a fine emulsion of hydrocarbon in the nitronium ion solution is formed with the hydrocarbon evenly distributed in the acid phase. The acid and the nitratable aromatic compound are brought into intimate contact in a plug-flow nitrator that contains mixing elements.

摘要翻译： 在氮化器中硝酸根离子溶液中硝化可硝化芳族化合物的连续方法。 该方法包括在硝酸，硫酸和水的三元相图中连接三个点所限定的区域内的组合物的硝化器硝鎓离子溶液中进料。 三点对应于首先约82％的硫酸和18％的硝酸，其次约55％的硫酸和约45％的水，以及第三种是100％的硫酸，硝酸优选低于3％左右。 引入可硝化芳族化合物，使得在硝酸根离子溶液中形成烃的精细乳液，其中均匀分布在酸相中的烃形成。 酸和可硝化芳香族化合物在包含混合元件的活塞式硝化器中紧密接触。

公开(公告)号：US5250741A

公开(公告)日：1993-10-05

申请号：US912372

申请日：1992-07-13

申请人： Robert J. Maleski

发明人： Robert J. Maleski

IPC分类号： C07C201/00 ,  C07C205/37 ,  C07C207/04 ,  C07C41/18 ,  C07C67/313 ,  C07C315/04

CPC分类号： C07C201/00 ,  C07C201/08

摘要： Disclosed is a process for the preparation of 5-alkoxy-2-nitrosophenols by the nitrosation of 3-alkoxyphenols using an alkali metal nitrite and an alkanoic acid wherein the selectivity of the nitrosation is improved. Also disclosed is a 2-step process for the preparation of 5-alkoxy-2-nitrophenols by oxidizing the 5-alkoxy-2-nitrosophenols obtained in accordance with the present invention.

摘要翻译： 公开了通过使用碱金属亚硝酸盐和链烷酸亚硝化3-烷氧基苯酚制备5-烷氧基-2-亚硝基苯酚的方法，其中亚硝化的选择性得到改善。 还公开了通过氧化根据本发明获得的5-烷氧基-2-亚硝基苯酚制备5-烷氧基-2-硝基苯酚的两步法。

公开(公告)号：US5225529A

公开(公告)日：1993-07-06

申请号：US471525

申请日：1990-01-29

申请人： Edoardo Butelman ,  Cesare Sirtori

发明人： Edoardo Butelman ,  Cesare Sirtori

IPC分类号： C07H15/02 ,  A61K31/70 ,  A61K31/7028 ,  A61P25/28 ,  C07C201/00 ,  C07H7/033 ,  C07H15/04 ,  C07H15/06 ,  C07H15/26 ,  C07H19/16 ,  C07K1/02 ,  C07K1/113 ,  C07K9/00 ,  C07K14/685 ,  C07K14/69 ,  C07K14/695

CPC分类号： C07H15/04 ,  C07H15/06 ,  C07H15/26 ,  C07H19/16 ,  C07H7/033 ,  C07K14/685 ,  C07K14/69 ,  C07K14/6955

摘要： Chemically and sterically pure synthetic amphiphilic glycoconjugates for neurological use of the formula (I): ##STR1## in which: the saccharide ring represents a monosaccharide such as glucose, galactose or mannose;X represents O or NH and, when X represents O, R is a choline radical whereas, when X represents NH, R is an amino acid or peptide radical; R' represents a saturated or unsaturated linear or branched C.sub.8 -C.sub.18 aliphatic chain, or a ##STR2## group where m is between 7 and 17 and; n is a whole number from 1 to 5.

公开(公告)号：US5220048A

公开(公告)日：1993-06-15

申请号：US356826

申请日：1989-05-24

申请人： Marcus Baumann ,  Walter Fischer ,  Vratislav Kvita ,  Carl W. Mayer

发明人： Marcus Baumann ,  Walter Fischer ,  Vratislav Kvita ,  Carl W. Mayer

IPC分类号： B05D1/20 ,  C07B37/10 ,  C07C17/00 ,  C07C17/23 ,  C07C23/18 ,  C07C25/22 ,  C07C41/00 ,  C07C43/225 ,  C07C43/29 ,  C07C63/68 ,  C07C65/26 ,  C07C67/00 ,  C07C69/76 ,  C07C201/00 ,  C07C205/11 ,  C07C205/12 ,  C07C205/46 ,  C07C233/65 ,  C07C235/46 ,  C07C255/52 ,  C07C323/09 ,  C07F7/08 ,  C08G61/12 ,  H01B1/12

CPC分类号： B05D1/202 ,  B82Y30/00 ,  B82Y40/00 ,  C07C205/11 ,  C07C205/46 ,  C07C25/22 ,  C07C43/225 ,  C07C69/76 ,  C07F7/0818 ,  C08G61/123 ,  H01B1/121 ,  C07C2102/06 ,  C07C2103/44

摘要： Benzocyclobutene-1,2-dichlorides, -bromides and -iodides which are substituted in the benzene ring are accessible in good yields and short reaction times by reacting substituted 1,2-(dichloromethyl or dibromomethyl)-benzenes with NaI in acetonitrile as the solvent. They can be used together with dienophils, for example 1,4-quinones, in Diels-Alder reactions.

摘要翻译： 在苯环中被取代的苯并环丁烯-1,2-二氯化物， - 溴化物和 - 碘化物可通过使取代的1,2-（二氯甲基或二溴甲基） - 苯与NaI在乙腈中作为溶剂而以良好的收率和短的反应时间获得 。 它们可以与Dien-Alder反应中的双亲体例如1,4-醌配合使用。

公开(公告)号：US5081315A

公开(公告)日：1992-01-14

申请号：US569615

申请日：1990-08-20

申请人： Jurgen Lau ,  Gunter Siegemund

发明人： Jurgen Lau ,  Gunter Siegemund

IPC分类号： C07B61/00 ,  B01J23/42 ,  B01J23/70 ,  C07C67/00 ,  C07C201/00 ,  C07C205/35 ,  C07C205/38 ,  C07C213/00 ,  C07C213/02 ,  C07C217/90 ,  C08G59/40 ,  C08G73/10 ,  C08G73/20

CPC分类号： C08G59/40 ,  C07C205/38 ,  C08G73/105 ,  C08G73/20 ,  Y10S526/937

摘要： Compounds of the formula ##STR1## in which A represents the radicals ##STR2## in which R.sup.1 and R.sup.2 are different from one another and denote hydrogen, --NO.sub.2 or --NH.sub.2, R.sup.3 is hydrogen or halogen, X represents --NO.sub.2 or --NH.sub.2, with the proviso that R.sup.1 is hydrogen, if R.sup.2 is --NO.sub.2 or --NH.sub.2 and R.sup.2 is hydrogen, if R.sup.1 is --NO.sub.2 or --NH.sub.2.The compounds are prepared from 4,4'-bis[2-(4-hydroxyphenyl)hexafluoroisopropyl]diphenyl ether by nitration or reaction with nitrobenzenes followed by reduction of the nitro groups. They are used for the preparation of high-temperature-resistant polycondensates.

公开(公告)号：US5073184A

公开(公告)日：1991-12-17

申请号：US506152

申请日：1990-04-09

申请人： Vivienne M. Anthony ,  John M. Clough ,  Paul deFraine ,  Christopher R. A. Godfrey ,  Kevin Beautement

发明人： Vivienne M. Anthony ,  John M. Clough ,  Paul deFraine ,  Christopher R. A. Godfrey ,  Kevin Beautement

IPC分类号： C07C241/00 ,  A01N37/36 ,  A01N37/42 ,  A01N37/44 ,  A01N37/48 ,  A01N43/06 ,  A01N43/08 ,  A01N43/10 ,  A01N43/36 ,  A01N43/38 ,  A01N43/58 ,  C07C67/00 ,  C07C69/734 ,  C07C201/00 ,  C07C205/56 ,  C07C229/64 ,  C07C233/58 ,  C07C239/00 ,  C07C245/06 ,  C07C251/02 ,  C07C251/44 ,  C07C253/00 ,  C07C255/57 ,  C07C255/59 ,  C07C309/63 ,  C07C313/00 ,  C07C323/54 ,  C07D207/32 ,  C07D207/337 ,  C07D207/34 ,  C07D209/18 ,  C07D307/42 ,  C07D307/54 ,  C07D307/79 ,  C07D333/24 ,  C07D333/32 ,  C07D333/34 ,  C07D333/38 ,  C07D333/60 ,  C07F7/18

CPC分类号： C07D207/337 ,  A01N43/06 ,  A01N43/36 ,  A01N43/38 ,  A01N43/58 ,  C07D209/18 ,  C07D307/54 ,  C07D307/79 ,  C07D333/24 ,  C07D333/60

摘要： Compounds of formula (I): ##STR1## and stereoisomers thereof, wherein W is R.sup.1 O.sub.2 C--C.dbd.CH--ZR.sup.2, wherein R.sup.1 and R.sup.2, which are the same or different, are alkyl or fluoroalkyl groups, and Z is either an oxygen or sulphur atom; A is an oxygen or sulphur atom, --NR.sup.3 --, or --CR.sup.4 R.sup.5 --; X, Y and Z.sup.1, which are the same or different, are hydrogen or halogen atoms, or hydroxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aralkyl, optionally substituted heteroarylalkyl, optionally substituted aryloxyalkyl, optionally substituted heteroaryloxyalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkoxy, optionally substituted arylalkoxy, optionally substituted aryloxy, optionally substituted heteraryloxy, optionally substituted acyloxy, optionally substituted amino, optionally substituted acylamino, optionally substituted arylazo, nitro, cyano, --CO.sub.2 R.sup.6, --CONR.sup.7 R.sup.8, --COR.sup.9 --CR.dbd.NR.sup.10, --CR.dbd.NOR.sup.10 or --N.dbd.CR.sup.11 R.sup.12 groups; or the groups X and Y, when they are in adjacent positions on the ring, optionally join to form a fused ring, either aromatic or aliphatic, optionally containing one or more heteroatoms; and R, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11 and R.sup.12, which are the same or different, are hydrogen atoms (provided that R.sup.4 and R.sup.5 are not hydrogen) or optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aralkyl, optionally substituted heterarylalkyl, optionally substituted aryloxyalkyl, optionally substituted heteroaryloxyalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl or optionally substituted heteroaryl groups; and metal compelxes thereof.The compounds are useful in agriculture, especially as fungicides but also as insecticides and plant growth regulators.

公开(公告)号：US5041691A

公开(公告)日：1991-08-20

申请号：US345517

申请日：1989-05-01

申请人： Willi Wuest ,  Rainer Eskuchen ,  Herbert Esser

发明人： Willi Wuest ,  Rainer Eskuchen ,  Herbert Esser

IPC分类号： C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/12 ,  C07C205/15

CPC分类号： C07C201/12

摘要： A process for reacting nitroparaffins with formaldehyde in the presence of potassium hydroxide by aldol condensation which can be carried out continuously or discontinuously and on a large scale. This is achieved by mixing the nitroparaffin, aqueous aldehyde solution and potassium hydroxide in the absence of organic solvents and carrying out the reaction while maintaining the temperature between -5.degree. and +20.degree. C.

摘要翻译： 在氢氧化钾存在下，通过醛醇缩合使硝基烷烃与甲醛反应的方法，其可以连续地或不连续地并且大规模地进行。 这是通过在不存在有机溶剂的情况下将硝基石蜡，醛水溶液和氢氧化钾混合并在保持温度在-5℃和+ 20℃之间进行反应来实现的。

公开(公告)号：US5041618A

公开(公告)日：1991-08-20

申请号：US367630

申请日：1989-06-19

申请人： Siegbert Brand ,  Bernd Wenderoth ,  Franz Schuetz ,  Hubert Sauter ,  Eberhard Ammermann ,  Gisela Lorenz

发明人： Siegbert Brand ,  Bernd Wenderoth ,  Franz Schuetz ,  Hubert Sauter ,  Eberhard Ammermann ,  Gisela Lorenz

IPC分类号： C07C69/618 ,  A01N37/10 ,  A01N37/34 ,  A01N37/36 ,  A01N37/38 ,  A01N37/40 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/36 ,  A01N43/50 ,  A01N43/56 ,  A01N43/647 ,  A01N43/653 ,  A01N43/713 ,  A01N43/76 ,  A01N43/78 ,  A01N43/80 ,  A01N43/82 ,  A01N47/02 ,  A01N47/18 ,  A01N47/22 ,  A01N53/00 ,  A01N53/10 ,  C07C67/00 ,  C07C69/732 ,  C07C69/734 ,  C07C69/736 ,  C07C201/00 ,  C07C205/53 ,  C07C229/44 ,  C07C233/54 ,  C07C233/55 ,  C07C233/65 ,  C07C233/66 ,  C07C233/75 ,  C07C233/81 ,  C07C235/56 ,  C07C241/00 ,  C07C245/06 ,  C07C317/44 ,  C07C323/56 ,  C07C323/62 ,  C07D277/74 ,  C07F9/54

CPC分类号： C07F9/5456 ,  A01N37/10 ,  A01N37/34 ,  A01N37/38 ,  A01N37/40 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/36 ,  A01N43/50 ,  A01N43/56 ,  A01N43/647 ,  A01N43/653 ,  A01N43/713 ,  A01N43/76 ,  A01N43/78 ,  A01N43/80 ,  A01N43/82 ,  A01N47/02 ,  A01N47/18 ,  A01N47/22 ,  A01N53/00 ,  C07C323/56 ,  C07C323/62 ,  C07D277/74

摘要： .alpha.-Arylacrylates of the general formula I ##STR1## where Y is substituted or unsubstituted, alkenylene, alkynylene, O,S(O).sub.m, N, oxycarbonyl, carbonyloxy, oxycarbonylalkylene, carbonyloxyalkylene, oxyalkyleneoxy, oxyalkylene, alkyleneoxy, thioalkylene, azo, carbonylamino, aminocarbonyl or aminocarbonyloxy, andZ is hydrogen, halogen, alkyl, alkenyl, cycloalkyl, alkynyl, aryl, arylalkyl, arylalkenyl, aryloxy, aryloxyalkyl, alkoxyalkyl, haloalkyl, aryloxyalkoxy, alkoxycarbonyl, which are substituted or unsubstituted, or is a 5-membered heterocyclic structure in which two adjacent substituents may form an aromatic or heteroaromatic ring,and fungicides containing these compounds.

摘要翻译： 其中Y是取代或未取代的亚烯基，亚炔基，O，S（O）m，N，氧羰基，羰氧基，氧羰基亚烷基，羰氧基亚烷基，氧亚烷基氧基，氧化烯，亚烷氧基，硫代亚烷基 ，偶氮，羰基氨基，氨基羰基或氨基羰氧基，Z为氢，卤素，烷基，烯基，环烷基，炔基，芳基，芳基烷基，芳基烯基，芳氧基，芳氧基烷基，烷氧基烷基，卤代烷基，芳氧基烷氧基，烷氧基羰基， 其中两个相邻的取代基可以形成芳族或杂芳族环的5元杂环结构，和含有这些化合物的杀真菌剂。