Invention Grant
- Patent Title: Pyrimidine-2,4-diamine derivative and anticancer pharmaceutical composition comprising same as effective ingredient
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Application No.: US15319151Application Date: 2015-05-21
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Publication No.: US10053458B2Publication Date: 2018-08-21
- Inventor: Chang Soo Yun , Hyoung Rae Kim , Sung Yun Cho , Hee Jung Jung , Kwangho Lee , Chong Hak Chae , Chong Ock Lee , Chi Hoon Park , Pilho Kim , Jong Yeon Hwang , Jae Du Ha , Sun Joo Ahn
- Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
- Applicant Address: KR Daejeon
- Assignee: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
- Current Assignee: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
- Current Assignee Address: KR Daejeon
- Agency: Ladas & Parry LLP
- Agent Loren K. Thompson
- Priority: KR10-2014-0073555 20140617
- International Application: PCT/KR2015/005118 WO 20150521
- International Announcement: WO2015/194764 WO 20151223
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D405/14 ; C07D401/14 ; C07D403/12 ; C07D401/12
Abstract:
The present invention relates to a pyrimidine-2,4-diamine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for prevention or treatment of cancer comprising the same as an effective ingredient. A compound according to the present invention has the good effect of inhibiting anaplastic lymphoma kinase (ALK) activity, whereby a therapeutic effect on cancer cells having an anaplastic lymphoma kinase (ALK) fusion protein such as EML4-ALK, NPM-ALK, etc. can be enhanced and it is expected that a recurrence of cancer will be effectively inhibited. As such, the compound can be effectively used in a pharmaceutical composition for prevention or treatment of cancer.
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