The present subject matter relates to systems and methods for selectively amplifying an acoustic signal in a closed environment. In an implementation, a plurality of acoustic signals may be received from within the closed environment. Frequency ranges corresponding to each acoustic signal may be obtained and compared to determine presence of at least one individual in the closed environment. Acoustic signals pertaining to the at least one individual may be analysed to detect occurrence of a physiological event. Based on the analysis, the acoustic signal may be recognized as a target signal, and the target signal may be amplified in the closed environment. Further, an interfering signal may be generated to cancel other acoustic signals within the closed environment.