A preform has a flange that protrudes outward at a neck, and is supplied in an inverted state. A preform handling device includes a star wheel that is configured so that the preform is supplied to each of a plurality of depressions that are formed in an outer circumferential part of a wheel, and pushes the preform to rotationally transfer the preform from an upstream region to a downstream region, an end face guide member that is provided in the upstream region so as to be situated under the preform and that support and guide an open end face of the preform, and a pair of flange guide members that are provided in the downstream region and that support and guide a lower side of the flange of the preform.