The present disclosure provides a pixel driving circuit, a display substrate and a driving method thereof, and a display device. The pixel driving circuit includes a driving unit, a data voltage write unit, an energy storage unit, a threshold compensation unit, and a touch driving compensation unit. The energy storage unit comprises a first energy storage end and a second energy storage end. The touch driving compensation unit is connected to the second energy storage end of the energy storage unit to compensate the voltage of the second energy storage end in a touch phase, so as to maintain that driving current generated by the driving unit does not vary with time. The pixel driving circuit provided by the present disclosure can allow luminance of a driven electroluminescent element does not vary with time in a touch phase, thereby avoiding affecting light emission display of the driven electroluminescent element.