An opening and closing mechanism for a roll-up cargo door for a truck is intended to decrease injuries to the people who load and unload items from box trucks and semi-trailers. The mechanism allows the user to open and close the overhead roll-up door of these trucks while standing firmly and safely on the ground at the rear corner of the truck. The door opening and closing mechanism is in the form of a loop of material that is attached to a lower portion of the roll-up door and a guide disposed near the top of the door frame. The loop includes an indicator that shows the user which side of the loop is to be pulled down depending on the position of the door. The mechanism can be retrofit onto existing truck frames.