Invention Grant
- Patent Title: Asymmetric catalytic decarboxylative alkyl alkylation using low catalyst concentrations and a robust precatalyst
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Application No.: US15081157Application Date: 2016-03-25
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Publication No.: US10106479B2Publication Date: 2018-10-23
- Inventor: Brian M. Stoltz , Alexander N. Marziale , Robert A. Craig , Douglas Duquette , Kelly E. Kim , Marc Liniger , Yoshitaka Numajiri
- Applicant: California Institute of Technology
- Applicant Address: US CA Pasadena
- Assignee: California Institute of Technology
- Current Assignee: California Institute of Technology
- Current Assignee Address: US CA Pasadena
- Agency: Foley Hoag LLP
- Main IPC: C07D211/94
- IPC: C07D211/94 ; C07C45/65 ; C07D223/10 ; C07D317/72 ; B01J31/04
Abstract:
This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II) or (III): with a palladium (II) catalyst under alkylation conditions.
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