公开(公告)号：US10106479B2

公开(公告)日：2018-10-23

申请号：US15081157

申请日：2016-03-25

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Alexander N. Marziale ,  Robert A. Craig ,  Douglas Duquette ,  Kelly E. Kim ,  Marc Liniger ,  Yoshitaka Numajiri

IPC: C07D211/94 ,  C07C45/65 ,  C07D223/10 ,  C07D317/72 ,  B01J31/04

Abstract: This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II) or (III): with a palladium (II) catalyst under alkylation conditions.

公开(公告)号：US20190055182A1

公开(公告)日：2019-02-21

申请号：US16166893

申请日：2018-10-22

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Alexander N. Marziale ,  Robert A. Craig ,  Douglas Duquette ,  Kelly E. Kim ,  Marc Liniger ,  Yoshitaka Numajiri

IPC: C07C45/65 ,  C07D211/94 ,  C07D223/10 ,  B01J31/04 ,  C07D317/72 ,  C07C49/647 ,  C07C49/683

Abstract: This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II) or (III): with a palladium (II) catalyst under alkylation conditions.