发明授权
- 专利标题： Synergistic enhancement of the delivery of nucleic acids via blended formulations
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申请号： US14775818申请日： 2014-03-14
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公开(公告)号： US10130649B2公开(公告)日： 2018-11-20
- 发明人: Frank Derosa , Lianne Smith , Michael Heartlein , Braydon Charles Guild
- 申请人： TRANSLATE BIO, INC.
- 申请人地址： US MA Lexington
- 专利权人： TRANSLATE BIO, INC.
- 当前专利权人： TRANSLATE BIO, INC.
- 当前专利权人地址： US MA Lexington
- 代理机构： Proskauer Rose, LLP
- 代理商 Fangli Chen
- 国际申请： PCT/US2014/028498 WO 20140314
- 国际公布： WO2014/144196 WO 20140918
- 主分类号： A61K9/127
- IPC分类号： A61K9/127 ; A61K31/7105 ; A61K9/14 ; A61K48/00 ; A61K9/00
摘要：
Disclosed herein are pharmaceutical compositions that comprise “blends” of lipid nanoparticles and related methods of using such blended compositions to deliver polynucleotides to one or more target cells, tissues or organs. The blended compositions are generally characterized as being able to efficiently deliver polynucleotides to target cells and by their ability to enhance the expression of such polynucleotides and the production of functional proteins by target cells.
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