公开(公告)号：US12084484B2

公开(公告)日：2024-09-10

申请号：US16937993

申请日：2020-07-24

申请人： VISTERRA, INC.

发明人： Scott Moore Carlson ,  Gregory Babcock ,  Zachary Shriver ,  Boopathy Ramakrishnan

IPC分类号： C07K14/55 ,  A61P13/12 ,  C07K16/24 ,  A61K38/00 ,  A61K39/00

CPC分类号： C07K14/55 ,  A61P13/12 ,  C07K16/246 ,  A61K38/00 ,  A61K2039/505 ,  C07K2319/31

摘要： IL-2 agents that comprise IL-2 variants are disclosed as well as methods, compositions, and uses thereof. The IL-2 agents described herein can be used to treat and/or prevent various disorders and conditions.

公开(公告)号：US12049499B2

公开(公告)日：2024-07-30

申请号：US17239010

申请日：2021-04-23

申请人： Millennium Pharmaceuticals, Inc.

发明人： Daniel Tavares ,  Bianka Prinz ,  James Geoghegan

IPC分类号： C07K16/28

CPC分类号： C07K16/2803 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/92

摘要： Antibodies, fragments thereof and fusion proteins that specifically bind to CD19, are described, as well as methods of making and using such antibodies. Such antibodies, fusion proteins and fragments thereof are useful for the treatment and diagnosis of various B-cell disorders, including B-cell malignancies and autoimmune diseases.

公开(公告)号：US11912781B2

公开(公告)日：2024-02-27

申请号：US17575420

申请日：2022-01-13

申请人： VISTERRA, INC.

发明人： Karthik Viswanathan ,  Brian Booth ,  Boopathy Ramakrishnan ,  Andrew Wollacott ,  Gregory Babcock ,  Zachary Shriver ,  Lauren Olinski

IPC分类号： C07K16/28 ,  A61P37/02 ,  A61K39/00

CPC分类号： C07K16/2896 ,  A61P37/02 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

摘要： The present disclosure provides, among other things, two different formats of humanized antibodies against human complement component 5a receptor I. The disclosure also provides a method of treating a subject having dysfunctions of C5a/C5aR1 axis pathway, including but not limited to ANCA-associated vasculitis, comprising administering to the subject in need thereof a an effective amount of antibody or a nucleic encoding an antibodies binding to C5aR1 described herein, and wherein administering results in a decrease in symptoms associated with C5a/C5aR1 associated dysfunction in the subject.

公开(公告)号：US11884945B2

公开(公告)日：2024-01-30

申请号：US17810396

申请日：2022-07-01

申请人： Takeda Pharmaceutical Company Limited

发明人： Dave Nichols ,  Igor Quinones-Garcia ,  Bee Lin Cheang ,  Mei Huei Jang

IPC分类号： C12N9/16 ,  A61K38/46 ,  C12M1/00

CPC分类号： C12N9/16 ,  A61K38/465 ,  C12M47/12 ,  C12Y301/06001 ,  C12Y301/06008

摘要： The present invention provides, among other things, improved methods for purifying arylsulfatase A (ASA) protein produced recombinantly for enzyme replacement therapy. The present invention is, in part, based on the surprising discovery that recombinant ASA protein can be purified from unprocessed biological materials, such as, ASA-containing cell culture medium, using a process involving as few as four chromatography columns and only one step of post-chromatographic ultrafiltration/diafiltration.

公开(公告)号：US11844765B2

公开(公告)日：2023-12-19

申请号：US18313134

申请日：2023-05-05

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Eben Tessari ,  John Paolini

IPC分类号： A61K38/20 ,  A61K47/68 ,  A61K38/17 ,  A61P9/00 ,  A61K39/395

CPC分类号： A61K38/2006 ,  A61K38/1709 ,  A61K38/1793 ,  A61K39/395 ,  A61K47/68 ,  A61K47/6811 ,  A61K47/6813 ,  A61P9/00

摘要： The present invention provides, among other things, methods of treating post-cardiac injury syndrome (PCIS) or pericarditis, comprising a step of administering to a subject in need of treatment an interleukin-1 receptor-Fc fusion protein at a therapeutically effective dose and an administration interval for a treatment period sufficient to improve, stabilize or reduce one or more signs and symptoms of pericarditis relative to a control.

公开(公告)号：US11730825B2

公开(公告)日：2023-08-22

申请号：US17558310

申请日：2021-12-21

申请人： Translate Bio, Inc.

发明人： Braydon Charles Guild ,  Frank DeRosa ,  Michael Heartlein

IPC分类号： A61K48/00 ,  A61K31/713 ,  A61K38/18 ,  A61K38/47 ,  A61K38/48 ,  A61K38/57 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  C07K14/505 ,  C07K14/81 ,  C12N15/52 ,  C12N15/85 ,  C12N9/40 ,  C12N9/64

CPC分类号： A61K48/0008 ,  A61K9/0019 ,  A61K9/0073 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/5123 ,  A61K31/713 ,  A61K38/1816 ,  A61K38/47 ,  A61K38/4846 ,  A61K38/57 ,  A61K48/0075 ,  A61K48/0091 ,  C07K14/505 ,  C07K14/8125 ,  C12N9/2465 ,  C12N9/644 ,  C12N15/52 ,  C12N15/85 ,  C12Y302/01022 ,  C12Y304/21022 ,  A61K48/00

摘要： Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.

公开(公告)号：US11547764B2

公开(公告)日：2023-01-10

申请号：US17556573

申请日：2021-12-20

申请人： Translate Bio, Inc.

发明人： Braydon Charles Guild ,  Frank DeRosa ,  Michael Heartlein

IPC分类号： A61K48/00 ,  A61K31/713 ,  A61K38/18 ,  A61K38/47 ,  A61K38/48 ,  A61K38/57 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  C07K14/505 ,  C07K14/81 ,  C12N15/52 ,  C12N15/85 ,  C12N9/40 ,  C12N9/64

摘要： Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.

公开(公告)号：US11524939B2

公开(公告)日：2022-12-13

申请号：US17095998

申请日：2020-11-12

申请人： Akebia Therapeutics, Inc.

发明人： Sudhir Ranjan ,  Xiaoyang Wang

IPC分类号： C07D213/81 ,  A61K9/00

摘要： Provided herein are solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid (Vadadustat, Code: AKB-6548, Compound 1), compositions comprising such solid forms, and methods of making and using thereof.

公开(公告)号：US11440681B2

公开(公告)日：2022-09-13

申请号：US17500119

申请日：2021-10-13

申请人： Nextant Aerospace

发明人： Mark O'Donnell

IPC分类号： B64F5/40 ,  B23P6/04

摘要： Systems and methods for repairing corrosion damage of a part of a thrust reverser assembly. The method includes removing the part having an inner surface and an outer surface. The method also includes removing an outer skin from the inner surface and the outer surface of the part. The method further includes installing a ply of synthetic fiber material onto an area of the inner surface or the outer surface of the part. The method also includes installing one or more doublers onto the ply of synthetic fiber material and heat curing layers of film adhesive. The method further includes applying an edge seal to gaps between the one or more doublers and the inner surface or outer surface of the part. The method also includes installing the outer skin to the inner surface and the outer surface of the part and installing the part to the thrust reverser assembly.

公开(公告)号：US11436942B2

公开(公告)日：2022-09-06

申请号：US16162221

申请日：2018-10-16

申请人： FMR LLC

发明人： Changjiu Shao ,  Yanyu Xu ,  Hongbing Gu ,  Ke Yang

IPC分类号： G09B21/00 ,  G06K9/00 ,  G06Q40/06 ,  H04M1/72481

摘要： An interactive braille display system includes a processor and a display unit in electronic communication with the processor. The display unit includes a braille cell unit and an interactive unit in physical contact with the braille cell unit. The interactive unit includes a surface layer for displaying braille information and sensing tactile contact by a user. The interactive unit also includes a subsurface layer in physical communication with the surface layer, the subsurface layer including electrodes for detecting a capacitance change caused by the tactile contact by the user. The capacitance change corresponds to a position of the tactile contact by the user.