Invention Grant
- Patent Title: Synergistic enhancement of the delivery of nucleic acids via blended formulations
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Application No.: US14775818Application Date: 2014-03-14
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Publication No.: US10130649B2Publication Date: 2018-11-20
- Inventor: Frank Derosa , Lianne Smith , Michael Heartlein , Braydon Charles Guild
- Applicant: TRANSLATE BIO, INC.
- Applicant Address: US MA Lexington
- Assignee: TRANSLATE BIO, INC.
- Current Assignee: TRANSLATE BIO, INC.
- Current Assignee Address: US MA Lexington
- Agency: Proskauer Rose, LLP
- Agent Fangli Chen
- International Application: PCT/US2014/028498 WO 20140314
- International Announcement: WO2014/144196 WO 20140918
- Main IPC: A61K9/127
- IPC: A61K9/127 ; A61K31/7105 ; A61K9/14 ; A61K48/00 ; A61K9/00

Abstract:
Disclosed herein are pharmaceutical compositions that comprise “blends” of lipid nanoparticles and related methods of using such blended compositions to deliver polynucleotides to one or more target cells, tissues or organs. The blended compositions are generally characterized as being able to efficiently deliver polynucleotides to target cells and by their ability to enhance the expression of such polynucleotides and the production of functional proteins by target cells.
Public/Granted literature
- US20160151409A1 SYNERGISTIC ENHANCEMENT OF THE DELIVERY OF NUCLEIC ACIDS VIA BLENDED FORMULATIONS Public/Granted day:2016-06-02
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