- 专利标题: Method of ex vivo enhancement of immune cell activity for cancer immunotherapy with a small molecule ablative compound
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申请号: US14974357申请日: 2015-12-18
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公开(公告)号: US10130658B2公开(公告)日: 2018-11-20
- 发明人: Jamie Singer , Eric Wachter , Amod Sarnaik , Shari Pilon-Thomas , Hao Liu
- 申请人: Jamie Singer , Eric Wachter , Amod Sarnaik , Shari Pilon-Thomas , Hao Liu
- 申请人地址: US TN Knoxville US FL Tampa
- 专利权人: Provectus Pharmatech, Inc.,H. Lee Moffitt Cancer Center and Research Institute, Inc.
- 当前专利权人: Provectus Pharmatech, Inc.,H. Lee Moffitt Cancer Center and Research Institute, Inc.
- 当前专利权人地址: US TN Knoxville US FL Tampa
- 代理机构: Husch Blackwell LLP
- 主分类号: A61K35/15
- IPC分类号: A61K35/15 ; A61K35/17 ; A61K38/17 ; A61K38/21 ; A61K39/00 ; C07K16/28 ; C12P21/00 ; A61K31/352 ; C12P21/02 ; A61K39/395
摘要:
A cancer immunotherapy method is disclosed in which “induced immune anticancer agents” are isolated after being induced in an animal host by intralesional (IL) administration of a halogenated xanthene tumor-ablative compound into a solid cancerous tumor of that host animal. A sample of the induced immune anticancer agents is removed (collected) from the tumor-bearing host, banked if desired, cultured and preferentially expanded to form an immunologically-effective enriched tumor-specific immune anticancer agent composition. That composition is reintroduced in to the host from which the predecessor induced immune anticancer agents were taken, or into another immunologically suitable host in need.
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