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    Intracorporeal medicaments for high energy phototherapeutic treatment of disease
    2.
    发明申请
    Intracorporeal medicaments for high energy phototherapeutic treatment of disease 有权
    用于高能量光疗治疗疾病的体内药物

    公开(公告)号：US20070208076A1

    公开(公告)日：2007-09-06

    申请号：US11715780

    申请日：2007-03-08

    申请人： H. Dees ,  Timothy Scott ,  Eric Wachter ,  Walter Fisher ,  John Smolik

    发明人： H. Dees ,  Timothy Scott ,  Eric Wachter ,  Walter Fisher ,  John Smolik

    IPC分类号： A61K31/352

    CPC分类号： A61K31/352

    摘要： New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes constitute a family of potent radiosensitizers that become photoactivated upon irradiation of the treatment site with ionizing radiation. In embodiments of the present invention, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.

    摘要翻译： 描述了新的体内放射碘化物药物和用于治疗人或动物组织的这种高能光疗药物的某些医学用途和方法，其中这种药物的主要活性成分是卤代呫吨或卤化呫吨衍生物。 卤化呫吨构成了一种有效的放射增敏剂，其在用电离辐射照射治疗部位时变得光活化。 在本发明的实施方案中，这些药物用于治疗影响皮肤和相关器官，口腔和消化道及相关器官，泌尿生殖道和相关器官，呼吸道及相关器官的各种病症， 循环系统和相关器官，头颈部，内分泌和淋巴系统及相关器官，各种其他组织，例如结缔组织和手术期间暴露的各种组织表面，以及表现出微生物或寄生虫感染的各种组织。 在另一个实施方案中，这些药物是以包括液体，半固体，固体或气溶胶输送载体在内的各种制剂生产的。

    Intracorporeal medicaments for high energy phototherapeutic treatment of disease
    7.
    发明申请
    Intracorporeal medicaments for high energy phototherapeutic treatment of disease 审中-公开
    用于高能量光疗治疗疾病的体内药物

    公开(公告)号：US20070078076A1

    公开(公告)日：2007-04-05

    申请号：US11542533

    申请日：2006-10-02

    申请人： H. Dees ,  Timothy Scott ,  Eric Wachter ,  Walter Fisher ,  John Smolik

    发明人： H. Dees ,  Timothy Scott ,  Eric Wachter ,  Walter Fisher ,  John Smolik

    IPC分类号： A61N5/00 ,  A61K48/00 ,  A61K38/17 ,  A61K31/365

    CPC分类号： A61K41/0038 ,  A61B2017/00057 ,  A61B2017/22062 ,  A61B2017/22087 ,  A61F7/00 ,  A61K9/0019 ,  A61K31/352 ,  A61K41/0057 ,  A61K41/008 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61K47/6803 ,  A61K49/0041 ,  A61K49/0433 ,  A61N5/0601 ,  A61N5/062 ,  C07D311/82 ,  Y10S436/813 ,  Y10S436/819

    摘要： New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes constitute a family of potent radiosensitizers that become photoactivated upon irradiation of the treatment site with ionizing radiation. In embodiments of the present invention, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection In another embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.

    摘要翻译： 描述了新的体内放射碘化物药物和用于治疗人或动物组织的这种高能光疗药物的某些医学用途和方法，其中这种药物的主要活性成分是卤代呫吨或卤化呫吨衍生物。 卤化呫吨构成了一种有效的放射增敏剂，其在用电离辐射照射治疗部位时变得光活化。 在本发明的实施方案中，这些药物用于治疗影响皮肤和相关器官，口腔和消化道及相关器官，泌尿生殖道和相关器官，呼吸道及相关器官的各种病症， 循环系统和相关器官，头颈部，内分泌和淋巴系统和相关器官，各种其他组织，例如在手术期间暴露的结缔组织和各种组织表面，以及显示微生物或寄生虫感染的各种组织。 ，这些药物是以各种制剂生产的，包括液体，半固体，固体或气溶胶递送载体。

    Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents
    9.
    发明申请
    Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents 有权
    用放射性标记的卤代呫吨酶诊断剂进行正电子发射成像的方法

    公开(公告)号：US20050276753A1

    公开(公告)日：2005-12-15

    申请号：US11050512

    申请日：2005-02-03

    申请人： Timothy Scott ,  H. Dees ,  Eric Wachter

    发明人： Timothy Scott ,  H. Dees ,  Eric Wachter

    IPC分类号： A61K51/00

    CPC分类号： A61K51/0421

    摘要： New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such agents is a radiolabeled halogenated xanthene or halogenated xanthene derivative. Preferably, the radiolabeled halogenated xanthene is radiolabeled Rose Bengal or a functional derivative of Rose Bengal.

    摘要翻译： 描述了用于正电子发射断层摄影（PET）的新诊断剂和用于这种药剂用于人或动物组织成像的方法，其中这种药剂的主要活性成分是放射性标记的卤化呫吨或卤代呫吨衍生物。 优选地，放射性标记的卤代呫吨是放射性标记的玫瑰红或玫瑰红的功能衍生物。

    Intracorporeal medicaments for photodynamic treatment of disease
    10.
    发明申请
    Intracorporeal medicaments for photodynamic treatment of disease 审中-公开
    用于光动力治疗疾病的体内药物

    公开(公告)号：US20070010575A1

    公开(公告)日：2007-01-11

    申请号：US11522145

    申请日：2006-09-15

    申请人： H. Dees ,  Timothy Scott ,  Eric Wachter ,  Walter Fisher ,  John Smolik

    发明人： H. Dees ,  Timothy Scott ,  Eric Wachter ,  Walter Fisher ,  John Smolik

    IPC分类号： A61K31/353

    CPC分类号： A61K31/352 ,  A61B2017/00057 ,  A61B2017/22062 ,  A61B2017/22087 ,  A61F7/00 ,  A61K9/0019 ,  A61K41/0038 ,  A61K41/0057 ,  A61K41/0071 ,  A61K41/008 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61K47/6803 ,  A61K49/0041 ,  A61K49/0433 ,  A61N5/0601 ,  A61N5/062 ,  C07D311/82 ,  Y02A50/473 ,  Y10T436/153333 ,  Y10T436/19 ,  Y10T436/193333

    摘要： New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.

    摘要翻译： 描述了新的体内光动力学药物和用于治疗人或动物组织中的这种光动力药物的某些医学用途和方法，其中这种药物的主要活性成分是卤代呫吨或卤代呫吨衍生物。 在优选的实施方案中，这些药物用于治疗影响皮肤和相关器官，口腔和消化道及相关器官，泌尿生殖道和相关器官，呼吸道及相关器官，循环系统 内脏和淋巴系统及相关器官，各种其他组织，如结缔组织和手术期间暴露的各种组织表面，以及表现出微生物或寄生虫感染的各种组织。 在另一个优选的实施方案中，这些药物以包括液体，半固体，固体或气溶胶递送载体的各种制剂生产。