发明授权
- 专利标题： Systems and methods for improved delivery of osteoinductive molecules in bone repair
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申请号： US14983008申请日： 2015-12-29
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公开(公告)号： US10130678B2公开(公告)日： 2018-11-20
- 发明人: Eric Vanderploeg , Howard Seeherman , Christopher G. Wilson , John Wozney , Christopher T. Brown , John A. Kambouris
- 申请人： BIOVENTUS, LLC
- 申请人地址： US NC Durham
- 专利权人： Bioventus, LLC.
- 当前专利权人： Bioventus, LLC.
- 当前专利权人地址： US NC Durham
- 代理机构： Kacvinsky Daisak Bluni PLLC
- 代理商 Judith Toffenetti
- 主分类号： A61L24/00
- IPC分类号： A61L24/00 ; A61L27/12 ; A61K38/17 ; A61K33/06 ; A61L27/44 ; A61L27/54 ; A61L27/56 ; A61K38/18 ; A61L24/02
摘要：
Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.
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