公开(公告)号：US10130678B2

公开(公告)日：2018-11-20

申请号：US14983008

申请日：2015-12-29

申请人： BIOVENTUS, LLC

发明人： Eric Vanderploeg ,  Howard Seeherman ,  Christopher G. Wilson ,  John Wozney ,  Christopher T. Brown ,  John A. Kambouris

IPC分类号： A61L24/00 ,  A61L27/12 ,  A61K38/17 ,  A61K33/06 ,  A61L27/44 ,  A61L27/54 ,  A61L27/56 ,  A61K38/18 ,  A61L24/02

摘要： Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.

公开(公告)号：US11452760B2

公开(公告)日：2022-09-27

申请号：US16151398

申请日：2018-10-04

申请人： Bioventus, LLC.

发明人： Eric Vanderploeg ,  Howard Seeherman ,  Christopher G. Wilson ,  John Wozney ,  Christopher T. Brown ,  John A. Kambouris

IPC分类号： A61K38/17 ,  A61K33/06 ,  A61L27/44 ,  A61L27/54 ,  A61L27/56 ,  A61K38/18 ,  A61L24/02 ,  A61L27/12 ,  A61L24/00

摘要： Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.

公开(公告)号：US20190070256A1

公开(公告)日：2019-03-07

申请号：US16151398

申请日：2018-10-04

申请人： Bioventus, LLC.

发明人： Eric Vanderploeg ,  Howard Seeherman ,  Christopher G. Wilson ,  John Wozney ,  Christopher T. Brown ,  John A. Kambouris

IPC分类号： A61K38/17 ,  A61K38/18 ,  A61L27/54 ,  A61L27/44 ,  A61K33/06 ,  A61L27/56 ,  A61L24/02 ,  A61L27/12 ,  A61L24/00 ,  C08L89/06

摘要： Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.