- 专利标题： Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid
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申请号： US15263149申请日： 2016-09-12
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公开(公告)号： US10150977B2公开(公告)日： 2018-12-11
- 发明人: Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Priti Pharkya
- 申请人： Genomatica, Inc.
- 申请人地址： US CA San Diego
- 专利权人： Genomatica, Inc.
- 当前专利权人： Genomatica, Inc.
- 当前专利权人地址： US CA San Diego
- 代理机构： Jones Day
- 主分类号： C12P17/10
- IPC分类号： C12P17/10 ; C12P13/00 ; C12N1/00 ; C12N1/16 ; C12N1/20 ; C12N15/70 ; C12N15/52 ; C07H21/04 ; C12N1/38 ; C12P7/40 ; C12P7/44 ; C12P13/02 ; C12P17/12
摘要：
The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.
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