Invention Grant
- Patent Title: 1-(3-aminopropyl) substituted cyclic amine compounds, preparation method therefor, and pharmaceutical compositions and uses thereof
-
Application No.: US15109101Application Date: 2014-12-29
-
Publication No.: US10167299B2Publication Date: 2019-01-01
- Inventor: Hong Liu , Beili Wu , Yongtang Zheng , Xin Xie , Hualiang Jiang , Panfeng Peng , Ronghua Luo , Jing Li , Jian Li , Ya Zhu , Ying Chen , Haonan Zhang , Liumeng Yang , Yu Zhou , Kaixian Chen
- Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Applicant Address: CN Shanghai
- Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Current Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Current Assignee Address: CN Shanghai
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- Priority: CN201310746752 20131230
- International Application: PCT/CN2014/095421 WO 20141229
- International Announcement: WO2015/101265 WO 20150709
- Main IPC: C07D519/00
- IPC: C07D519/00 ; C07D409/14 ; C07D451/04 ; C07D401/14 ; A61K45/06 ; A61K31/46 ; A61K31/4545 ; A61K31/454
Abstract:
Provided are 1-(3-aminopropyl) substituted cyclic amine compounds as represented by frmula (I), pharmaceutically acceptable salts, enantiomers, diastereoisomers, racemates and mixtures thereof, and a method of synthesizing said 1-(3-aminopropyl) substituted cyclic amine compounds by using aromatic heterocyclic formaldehyde as raw material. Said compounds can be used as CCR 5 antagonist for the treatment of HIV infection.
Public/Granted literature
Information query
