公开(公告)号：US10167299B2

公开(公告)日：2019-01-01

申请号：US15109101

申请日：2014-12-29

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Hong Liu ,  Beili Wu ,  Yongtang Zheng ,  Xin Xie ,  Hualiang Jiang ,  Panfeng Peng ,  Ronghua Luo ,  Jing Li ,  Jian Li ,  Ya Zhu ,  Ying Chen ,  Haonan Zhang ,  Liumeng Yang ,  Yu Zhou ,  Kaixian Chen

IPC: C07D519/00 ,  C07D409/14 ,  C07D451/04 ,  C07D401/14 ,  A61K45/06 ,  A61K31/46 ,  A61K31/4545 ,  A61K31/454

Abstract: Provided are 1-(3-aminopropyl) substituted cyclic amine compounds as represented by frmula (I), pharmaceutically acceptable salts, enantiomers, diastereoisomers, racemates and mixtures thereof, and a method of synthesizing said 1-(3-aminopropyl) substituted cyclic amine compounds by using aromatic heterocyclic formaldehyde as raw material. Said compounds can be used as CCR 5 antagonist for the treatment of HIV infection.