The inventions disclosed herein include methods, systems, and tools for use in processing prescriptions. Among the benefits of these methods, systems, and tools are promotion of efficiency in filling prescriptions and reduction of errors. A heightened analysis element may be established that alerts a pharmaceutical professional to a particular component of a prescription (a prescription element) for special attention. An insignificant differences notice may de-emphasize certain prescription elements to inform a pharmaceutical professional that the information of such prescription elements is less critical. Methods of the present invention may be used to designate a prescription as a renewal, partial renewal, or partially equivalent renewal. The disclosed inventions include methods of creating and/or using such heightened analysis elements, insignificant differences notices, and/or designation of a prescription as a renewal, partial renewal, or partially equivalent renewal.