A pair of safe pet nail clippers includes a first handle and a second handle correspondingly disposed and pivotedly connected to each other. The first and second handles respectively include a blade portion and a handle portion. Blades of the blade portions of the first and second handles are provided in a concave shape. When the handle portions of the first and second handles are relatively opened to the maximum extent, an initial trimming hole is formed between the concave blades of the first and second handles. The first and second handles are provided therebetween with an adjustment mechanism for adjusting the relative opening of the handle portions of the first and second handles and the caliber of the initial trimming hole.