A system and process for detecting dynamic segregation in concrete rotated within a mixer drum, such as mounted on a delivery truck. A system processor is programmed to monitor an instantaneous and averaged rheology parameter and to deploy protocols for detecting segregation. A first protocol comprises monitoring the averaged slump during and immediately after a jump in drum speed of at least plus or minus four rotations per minute and detecting when a change in the averaged slump value meets or exceeds a threshold; and a second protocol comprises monitoring the instantaneous slump when the mixer drum is rotating at a constant speed for at least three successive rotations and detecting when the instantaneous slump value meets or exceeds a threshold limit. Once segregation is detected, one or more operations can be initiated, such as initiating an alarm or adjusting the mix.