- 专利标题： Stabilized STAT3 decoy oligonucleotides and uses therefor
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申请号： US15611298申请日： 2017-06-01
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公开(公告)号： US10183977B2公开(公告)日： 2019-01-22
- 发明人: Jennifer R. Grandis , Daniel E. Johnson , Danith Ly
- 申请人： UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , CARNEGIE MELLON UNIVERSITY
- 申请人地址： US PA Pittsburgh US PA Pittsburgh
- 专利权人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION,CARNEGIE MELLON UNIVERSITY
- 当前专利权人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION,CARNEGIE MELLON UNIVERSITY
- 当前专利权人地址： US PA Pittsburgh US PA Pittsburgh
- 代理机构： Baker Botts L.L.P.
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H21/04 ; A61K31/70 ; C07K14/47 ; A61K45/06 ; C12N15/113 ; C12N15/115 ; A61K31/713 ; A61K39/395 ; A61N5/00 ; C12N5/00 ; A61K39/00
摘要：
The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are effective in inhibiting STAT3 when administered systemically. The invention is also based on pharmaceutical compositions comprising these unimolecular decoys, and methods for using these decoys in the treatment of cancer.
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