An earth-boring drill bit is described, the bit having a bit body having a central longitudinal axis that defines an axial center of the bit body and configured at its upper extent for connection into a drill string; at least one primary fixed blade extending downwardly from the bit body and inwardly toward, but not proximate to, the central axis of the drill bit; at least one secondary fixed blade extending radially outward from proximate the central axis of the drill bit; a plurality of fixed cutting elements secured to the primary and secondary fixed blades; at least one bit leg secured to the bit body; and a rolling cutter mounted for rotation on the bit leg; wherein the fixed cutting elements on at least one fixed blade extend from a center of the bit outward toward a gage region of the bit but do not include a gage cutting region, and wherein at least one roller-cone cutter portion extends from substantially the drill bit's gage region inwardly toward the center of the bit, an apex of the roller-cone cutter being proximate to the terminal end of the at least one secondary fixed blade, but does not extend to the center of the bit.