Disclosed herein are a method of performing a Coordinated Multi-Point (CoMP) operation in a wireless communication system and an apparatus for supporting the same. A method of performing an inter-eNB CoMP operation in a wireless communication system includes receiving, by a first eNB, a first LOAD INFORMATION message that requests the start of the CoMP operation from a second eNB, sending, by the first eNB, a second LOAD INFORMATION message for requesting Benefit Metric Information Element (IE) to the second eNB, receiving, by the first eNB, a third LOAD INFORMATION message, including the Benefit Metric IE from the second eNB, coordinating, by the first eNB, the resources of the eNBs included in the CoMP cluster, and sending, by the first eNB, a second LOAD INFORMATION message including results of the resource coordination to the eNBs included in the CoMP cluster.