- 专利标题: Induction of mucosal tolerance to antigens
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申请号: US15331020申请日: 2016-10-21
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公开(公告)号: US10195269B2公开(公告)日: 2019-02-05
- 发明人: Pieter Rottiers , Veerle Snoeck
- 申请人: INTREXON ACTOBIOTICS NV
- 申请人地址: BE Zwijnaarde
- 专利权人: INTREXON ACTOBIOTICS NV
- 当前专利权人: INTREXON ACTOBIOTICS NV
- 当前专利权人地址: BE Zwijnaarde
- 代理机构: Drinker Biddle & Reath LLP
- 优先权: EP05111467 20051129
- 主分类号: A61K39/39
- IPC分类号: A61K39/39 ; A61K39/35 ; A61K35/747 ; A61K38/20 ; A61K39/00 ; A61K35/74 ; A61K39/395 ; A23K10/18 ; A23K50/20 ; A23K50/10 ; A23K50/30 ; A23K50/40 ; A23K50/50 ; A23L33/135 ; C07K16/28 ; A61K36/064
摘要:
The present invention relates to the induction of tolerance to antigens, by mucosal, preferably oral delivery of the antigen in combination with an immunomodulating compound producing micro-organism. More specifically, the invention relates to the induction of Foxp3+ and/or IL-10 and/or TGF-β producing regulatory T-cells, capable of suppressing undesired immune responses toward an antigen, by oral delivery of said antigen in combination with an immunosuppressing cytokine secreting micro-organism.
公开/授权文献
- US20170100475A1 INDUCTION OF MUCOSAL TOLERANCE TO ANTIGENS 公开/授权日:2017-04-13