Invention Grant
- Patent Title: Method of increasing the bioavailability of an HIV drug
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Application No.: US14916803Application Date: 2014-09-05
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Publication No.: US10201552B2Publication Date: 2019-02-12
- Inventor: Pradeep K. Karla
- Applicant: HOWARD UNIVERSITY
- Applicant Address: US DC
- Assignee: Howard University
- Current Assignee: Howard University
- Current Assignee Address: US DC
- Agency: Fitch, Even, Tabin & Flannery, LLP
- International Application: PCT/US2014/054367 WO 20140905
- International Announcement: WO2015/035218 WO 20150312
- Main IPC: A61K31/675
- IPC: A61K31/675 ; A61K9/06 ; A61K31/47 ; A61K45/06 ; A61K31/4745 ; A61K31/4985 ; A61K9/00

Abstract:
Methods and compositions are provided for reducing transmission and/or infection of HIV in a subject by increasing the bioavailability of a drug in the subject. The methods and compositions provided herein include an efflux transporter inhibitor and a drug effective for reducing the transmission and/or infection of HIV in a subject. The efflux transporter inhibitor is effective to reduce the efflux of the drug through at least one of P-glycoprotein (Pgp), breast cancer resistant protein (BCRP), and multidrug resistant associated protein 1-9 (MRP1-9).
Public/Granted literature
- US20160193237A1 Method Of Increasing The Bioavailability Of An HIV Drug Public/Granted day:2016-07-07
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