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    Method Of Increasing The Bioavailability Of An HIV Drug
    1.
    发明申请
    Method Of Increasing The Bioavailability Of An HIV Drug 审中-公开
    增加HIV药物生物利用度的方法

    公开(公告)号：US20160193237A1

    公开(公告)日：2016-07-07

    申请号：US14916803

    申请日：2014-09-05

    Applicant: HOWARD UNIVERSITY

    Inventor： Pradeep K. Karla

    IPC: A61K31/675 ,  A61K9/00 ,  A61K45/06 ,  A61K9/06

    CPC classification number: A61K31/675 ,  A61K9/0034 ,  A61K9/06 ,  A61K31/47 ,  A61K31/4745 ,  A61K31/4985 ,  A61K45/06 ,  A61K2300/00

    Abstract: Methods and compositions are provided for reducing transmission and/or infection of HIV in a subject by increasing the bioavailability of a drug in the subject. The methods and compositions provided herein include an efflux transporter inhibitor and a drug effective for reducing the transmission and/or infection of HIV in a subject. The efflux transporter inhibitor is effective to reduce the efflux of the drug through at least one of P-glycoprotein (Pgp), breast cancer resistant protein (BCRP), and multidrug resistant associated protein 1-9 (MRP1-9).

    Abstract translation: 提供了通过增加受试者中药物的生物利用度来减少受试者中HIV的传播和/或感染的方法和组合物。 本文提供的方法和组合物包括外排转运蛋白抑制剂和有效减少受试者中HIV传播和/或感染的药物。 流出转运蛋白抑制剂通过P-糖蛋白（Pgp），乳腺癌耐药蛋白（BCRP）和多药耐药相关蛋白1-9（MRP1-9）中的至少一种有效减少药物的流出。

    Method Of Treating An Ocular Disease And Compositions Effective For Treating An Ocular Disease
    5.
    发明申请
    Method Of Treating An Ocular Disease And Compositions Effective For Treating An Ocular Disease 审中-公开
    治疗有效治疗眼病的眼病和组合物的方法

    公开(公告)号：US20140045741A1

    公开(公告)日：2014-02-13

    申请号：US14059035

    申请日：2013-10-21

    Applicant: Howard University

    Inventor： Pradeep K. Karla ,  Harpal S. Mangat

    IPC: A61K38/13

    CPC classification number: A61K38/13 ,  A61K9/0048 ,  A61K31/496 ,  A61K31/53 ,  A61K31/546 ,  A61K31/573 ,  A61K38/14 ,  A61K2300/00

    Abstract: Methods and compositions are provided for treating an ocular disease in a subject in need thereof by increasing the bioavailability of a drug in the subject's eye. In one aspect, the ocular disease is at least one of diabetic retinopathy, macular degeneration, endopthalmitis, glaucoma, cataracts, ocular herpes. The methods and compositions provided herein include an efflux transporter inhibitor and a drug effective for treating the ocular disease. The efflux transporter inhibitor is effective to reduce the efflux of the drug through at least one of P-glycoprotein (Pgp), breast cancer resistant protein (BCRP), and multidrug resistant associated protein 1-9 (MRP1-9).

    Abstract translation: 提供了通过增加受试者眼睛中药物的生物利用度来治疗有需要的受试者的眼部疾病的方法和组合物。 一方面，眼部疾病是糖尿病性视网膜病变，黄斑变性，内耳炎，青光眼，白内障，眼疱疹中的至少一种。 本文提供的方法和组合物包括外排转运蛋白抑制剂和有效治疗眼部疾病的药物。 流出转运蛋白抑制剂通过P-糖蛋白（Pgp），乳腺癌耐药蛋白（BCRP）和多药耐药相关蛋白1-9（MRP1-9）中的至少一种有效减少药物的流出。

    Method Of Treating An Ocular Disease And Compositions Effective For Treating An Ocular Disease
    7.
    发明申请
    Method Of Treating An Ocular Disease And Compositions Effective For Treating An Ocular Disease 审中-公开
    治疗有效治疗眼病的眼病和组合物的方法

    公开(公告)号：US20150352177A1

    公开(公告)日：2015-12-10

    申请号：US14831030

    申请日：2015-08-20

    Applicant: Howard University

    Inventor： Pradeep K. Karla ,  Harpal S. Mangat

    IPC: A61K38/13 ,  A61K31/573 ,  A61K38/14 ,  A61K9/00 ,  A61K31/546

    CPC classification number: A61K38/13 ,  A61K9/0048 ,  A61K31/496 ,  A61K31/53 ,  A61K31/546 ,  A61K31/573 ,  A61K38/14 ,  A61K2300/00

    Abstract: Methods and compositions are provided for treating an ocular disease in a subject in need thereof by increasing the bioavailability of a drug in the subject's eye. In one aspect, the ocular disease is at least one of diabetic retinopathy, macular degeneration, endopthalmitis, glaucoma, cataracts, ocular herpes. The methods and compositions provided herein include an efflux transporter inhibitor and a drug effective for treating the ocular disease. The efflux transporter inhibitor is effective to reduce the efflux of the drug through at least one of P-glycoprotein (Pgp), breast cancer resistant protein (BCRP), and multidrug resistant associated protein 1-9 (MRP1-9).

    Abstract translation: 提供了通过增加受试者眼睛中药物的生物利用度来治疗有需要的受试者的眼部疾病的方法和组合物。 一方面，眼部疾病是糖尿病性视网膜病变，黄斑变性，内耳炎，青光眼，白内障，眼疱疹中的至少一种。 本文提供的方法和组合物包括外排转运蛋白抑制剂和有效治疗眼部疾病的药物。 流出转运蛋白抑制剂通过P-糖蛋白（Pgp），乳腺癌耐药蛋白（BCRP）和多药耐药相关蛋白1-9（MRP1-9）中的至少一种有效减少药物的流出。

    Method of increasing the bioavailability of an HIV drug
    8.
    发明授权
    Method of increasing the bioavailability of an HIV drug 有权

    公开(公告)号：US10201552B2

    公开(公告)日：2019-02-12

    申请号：US14916803

    申请日：2014-09-05

    Applicant: HOWARD UNIVERSITY

    Inventor： Pradeep K. Karla

    IPC: A61K31/675 ,  A61K9/06 ,  A61K31/47 ,  A61K45/06 ,  A61K31/4745 ,  A61K31/4985 ,  A61K9/00

    Abstract: Methods and compositions are provided for reducing transmission and/or infection of HIV in a subject by increasing the bioavailability of a drug in the subject. The methods and compositions provided herein include an efflux transporter inhibitor and a drug effective for reducing the transmission and/or infection of HIV in a subject. The efflux transporter inhibitor is effective to reduce the efflux of the drug through at least one of P-glycoprotein (Pgp), breast cancer resistant protein (BCRP), and multidrug resistant associated protein 1-9 (MRP1-9).

    Method Of Treating An Ocular Disease And Compositions Effective For Treating An Ocular Disease
    9.
    发明申请
    Method Of Treating An Ocular Disease And Compositions Effective For Treating An Ocular Disease 审中-公开
    治疗有效治疗眼病的眼病和组合物的方法

    公开(公告)号：US20150111833A1

    公开(公告)日：2015-04-23

    申请号：US14395384

    申请日：2013-03-15

    Applicant: Howard University

    Inventor： Pradeep K. Karla ,  Harpal S. Mangat

    IPC: A61K38/13 ,  A61K9/00 ,  A61K31/573 ,  A61K31/496 ,  A61K31/546

    CPC classification number: A61K38/13 ,  A61K9/0048 ,  A61K31/496 ,  A61K31/53 ,  A61K31/546 ,  A61K31/573 ,  A61K38/14 ,  A61K2300/00

    Abstract: Methods and compositions are provided for treating an ocular disease in a subject in need thereof by increasing the bioavailability of a drug in the subjects eye. By one approach, the ocular disease is endophthalmitis. The methods and compositions provided herein include an efflux transporter inhibitor and a drug effective for treating the ocular disease. The efflux transporter inhibitor is effective to reduce the efflux of the drug through at least one of Pglycoprotein (Pgp), breast cancer resistant protein (BCRP), and multidrug resistant associated protein 19 (MRP19). In one aspect, cyclosporine A is the efflux transporter inhibitor.

    Abstract translation: 提供了通过增加受试者眼睛中药物的生物利用度来治疗有需要的受试者的眼部疾病的方法和组合物。 通过一种方法，眼部疾病是眼内炎。 本文提供的方法和组合物包括外排转运蛋白抑制剂和有效治疗眼部疾病的药物。 流出转运蛋白抑制剂通过至少一种糖蛋白（Pgp），乳腺癌抗性蛋白（BCRP）和多药耐药相关蛋白19（MRP19）中的至少一种有效减少药物的流出。 一方面，环孢菌素A是外排转运蛋白抑制剂。

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