- 专利标题： 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors
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申请号： US15548925申请日： 2016-02-05
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公开(公告)号： US10202365B2公开(公告)日： 2019-02-12
- 发明人: Natasja Brooijmans , Lucian V. DiPietro , Paul E. Fleming , Joseph L. Kim , Steven Mark Wenglowsky , Yulian Zhang
- 申请人： BLUEPRINT MEDICINES CORPORATION
- 申请人地址： US MA Cambridge
- 专利权人： BLUEPRINT MEDICINES CORPORATION
- 当前专利权人： BLUEPRINT MEDICINES CORPORATION
- 当前专利权人地址： US MA Cambridge
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- 国际申请： PCT/US2016/016808 WO 20160205
- 国际公布： WO2016/127074 WO 20160811
- 主分类号： A61K31/506
- IPC分类号： A61K31/506 ; C07D401/14 ; C07D403/12 ; C07D405/14 ; C07D403/04 ; C07D417/14 ; A61K45/06
摘要：
Described herein are compounds, such as compounds of Formula (I) and pharmaceutically acceptable salts thereof, that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions, e.g., for treating a condition mediated by aberrant RET activity
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